RN 1 dihydrochloride

Cat. No. 4977

RN 1 dihydrochloride C23H29N3O2.2HCl [1781835-13-9]

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Chemical Name: 1-(4-methyl-1-piperazinyl)-2-[[(1R*,2S*)-2-[4-phenylmethoxy)phenyl]cyclopropyl]amino]ethanone dihydrochloride

Biological Activity

Potent lysine specific demethylase 1 (LSD1) inhibitor (IC50 = 70 nM). Exhibits selectivity for LSD1 over MAO-A and MAO-B (IC50 values are 0.51 and 2.79 μM for MAO-A and MAO-B, respectively). Impairs long-term, but not short-term memory in mice. Brain penetrant following systemic administration.

Technical Data

Soluble to 20 mM in water and to 20 mM in DMSO
>97 %
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Neelamegam et al (2012) Brain-penetrant LSD1 inhibitors can block memory consolidation. ACS Chem.Neurosci. 3 120. PMID: 22754608.

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Keywords: RN 1 dihydrochloride, supplier, RN1, dihydrochloride, LSD1, lysine-specific, demethylase, 1, histone, demethylases, monoamine, oxidases, MAOs, inhibitors, inhibits, selective, Tocris Bioscience, Histone Demethylase Inhibitor products

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