Cat. No. 4976
Chemical Name: [(3R)-3-(Hydroxymethyl)-1-pipridiny
Biological ActivitySelective negative allosteric modulator at mGlu3 receptors (IC50 = 660 nM). Exhibits 15-fold selectivity for mGlu3 over mGlu2. Centrally penetrant.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Sheffler et al (2012) Development of a novel, CNS-penetrant, metabotropic glutamate receptor 3 (mGlu3) NAM probe (ML289) derived from a closely related mGlu5 PAM. Bioorg.Med.Chem.Lett. 22 3921. PMID: 22607673.
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Keywords: ML 289, supplier, ML289, selective, allosteric, modulators, mglu3, mglu_3, metabotropic, glutamate, receptors, NAMs, group, II, 2, Tocris Bioscience, Glutamate (Metabotropic) Group II Receptor Modulator products
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