Cat. No. 4976
Chemical Name: [(3R)-3-(Hydroxymethyl)-1-pipridiny
Biological ActivitySelective negative allosteric modulator at mGlu3 receptors (IC50 = 660 nM). Exhibits 15-fold selectivity for mGlu3 over mGlu2. Centrally penetrant.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Sheffler et al (2012) Development of a novel, CNS-penetrant, metabotropic glutamate receptor 3 (mGlu3) NAM probe (ML289) derived from a closely related mGlu5 PAM. Bioorg.Med.Chem.Lett. 22 3921. PMID: 22607673.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses ML 289 from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: ML 289, supplier, ML289, selective, allosteric, modulators, mglu3, mglu_3, metabotropic, glutamate, receptors, NAMs, group, II, 2, Tocris Bioscience, Glutamate (Metabotropic) Group II Receptor Modulator products
Find multiple products by catalog number
New Products in this Area
Negative allosteric modulator at mGlu7; brain penetrantVU 0409551
Selective mGlu5 positive allosteric modulator; brain penetrant and orally bioavailable
December 13 - 15, 2016