JIB 04

Cat. No. 4972

JIB 04 C17H13ClN4 [199596-05-9]

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Chemical Name: 5-Chloro-2-[(E)-2-[phenyl(pyridin-2-yl)methylidene]hydrazin-1-yl]pyridine

Biological Activity

Pan Jumonji histone demethylase inhibitor (IC50 values are 230, 340, 435, 445, 855 and 1100 nM for JARID1A, JMJD2E, JMJD2B, JMJD2A, JMJD3 and JMJD2C respectively). Exhibits negligible activity at PHD2 and TET1. Selectively blocks cancer cell growth in vitro and diminishes tumor growth in H358 and A549 mouse xenograft models in vivo. Prolongs survival in a mouse model of breast cancer.

Technical Data

Soluble to 100 mM in DMSO and to 50 mM in 1eq. HCl
>99 %
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Wang et al (2013) A small molecule modulates Jumonji histone demethylase activity and selectively inhibits cancer growth. Nat. Commun. 4 2035. PMID: 23792809.

Grunicke and Hofmann (1997) Azinyl and diazinyl hydrazones derived from aryl N-heteroaryl ketones: synthesis and antiproliferative activity. J. Med. Chem. 40 4420. PMID: 9435912.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for JIB 04 include:

Lee et al (2016) Signalling couples hair follicle stem cell quiescence with reduced histone H3 K4/K9/K27me3 for proper tissue homeostasis. Nat Commun 7 11278. PMID: 27080563.

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Keywords: JIB 04, supplier, JIB04, histone, demethylases, inhibits, inhibitors, JMJ, JARID1A, JMJD2A, JMJD2B, JMJD2C, JMJD2E, JMJD3, pan, selective, antiproliferative, Tocris Bioscience, Histone Demethylase Inhibitor products

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