Cat. No. 4972
Chemical Name: 5-Chloro-2-[(E)-2-[phenyl(pyridin-2
Biological ActivityPan Jumonji histone demethylase inhibitor (IC50 values are 230, 340, 435, 445, 855 and 1100 nM for JARID1A, JMJD2E, JMJD2B, JMJD2A, JMJD3 and JMJD2C respectively). Exhibits negligible activity at PHD2 and TET1. Selectively blocks cancer cell growth in vitro and diminishes tumor growth in H358 and A549 mouse xenograft models in vivo. Prolongs survival in a mouse model of breast cancer.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Wang et al (2013) A small molecule modulates Jumonji histone demethylase activity and selectively inhibits cancer growth. Nat. Commun. 4 2035. PMID: 23792809.
Grunicke and Hofmann (1997) Azinyl and diazinyl hydrazones derived from aryl N-heteroaryl ketones: synthesis and antiproliferative activity. J. Med. Chem. 40 4420. PMID: 9435912.
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Citations are publications that use Tocris products. Selected citations for JIB 04 include:
Lee et al (2016) Signalling couples hair follicle stem cell quiescence with reduced histone H3 K4/K9/K27me3 for proper tissue homeostasis. Nat Commun 7 11278. PMID: 27080563.
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Keywords: JIB 04, supplier, JIB04, histone, demethylases, inhibits, inhibitors, JMJ, JARID1A, JMJD2A, JMJD2B, JMJD2C, JMJD2E, JMJD3, pan, selective, antiproliferative, Tocris Bioscience, Histone Demethylase Inhibitor products