SC 144 hydrochloride

Cat. No. 4963

SC 144 hydrochloride C16H11FN6O.HCl [917497-70-2]

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Chemical Name: 2-(7-Fluoropyrrolo[1,2-a]quinoxalin-4-yl) 2-pyrazinecarboxylic acid hydrazide hydrochloride

Biological Activity

Inhibitor of gp130 (IC50 = 0.72 μM); blocks cytokine-triggered gp130 signaling. Induces gp130 phosphorylation and down regulates gp130 glycosylation; also abrogates STAT3 phosphorylation, nuclear translocation and inhibits the expression of downstream target genes. Delays tumor growth in a mouse xenograft model of human ovarian cancer. Orally active.

Technical Data

M.Wt:
358.76
Formula:
C16H11FN6O.HCl
Solubility:
Soluble to 100 mM in DMSO
Purity:
>99 %
Storage:
Store at -20°C
CAS No:
917497-70-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Xu et al (2013) Discovery of a novel orally active small-molecule gp130 inhibitor for the treatment of ovarian cancer. Mol.Cancer Ther. 12 937. PMID: 23536726.

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Keywords: SC 144 hydrochloride, supplier, SC144, hydrochloride, GP130, inhibitors, inhibits, blocks, cytokine, triggered, gp130, signaling, signalling, Stat3, nuclear, translocation, ovarian, cancer, Tocris Bioscience, Cytokine products

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