SC 144 hydrochloride
Cat. No. 4963
Chemical Name: 2-(7-Fluoropyrrolo[1,2-a]quinoxalin
Biological ActivityInhibitor of gp130 (IC50 = 0.72 μM); blocks cytokine-triggered gp130 signaling. Induces gp130 phosphorylation and down regulates gp130 glycosylation; also abrogates STAT3 phosphorylation, nuclear translocation and inhibits the expression of downstream target genes. Delays tumor growth in a mouse xenograft model of human ovarian cancer. Orally active.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Xu et al (2013) Discovery of a novel orally active small-molecule gp130 inhibitor for the treatment of ovarian cancer. Mol.Cancer Ther. 12 937. PMID: 23536726.
If you know of a relevant reference for SC 144 hydrochloride please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses SC 144 hydrochloride from Tocris? If so please let us know.
View Related Products by Product Action
Keywords: SC 144 hydrochloride, supplier, SC144, hydrochloride, GP130, inhibitors, inhibits, blocks, cytokine, triggered, gp130, signaling, signalling, Stat3, nuclear, translocation, ovarian, cancer, Tocris Bioscience, Cytokine products
Find multiple products by catalog number
New Products in this Area
Receptor for advanced glycation end products (RAGE) antagonistGaliellalactone
STAT3 inhibitor; active in vivoCP 424174
Inhibitor of IL-1β post-translational processing; indirectly inhibits NLRP3IT 901
NF-κB c-Rel subunit inhibitor
Follow Tocris on LinkedIn
Visit our LinkedIn page for the latest Tocris news, events and updates.