SC 144 hydrochloride
Cat. No. 4963
Chemical Name: 2-(7-Fluoropyrrolo[1,2-a]quinoxalin
Biological ActivityInhibitor of gp130 (IC50 = 0.72 μM); blocks cytokine-triggered gp130 signaling. Induces gp130 phosphorylation and down regulates gp130 glycosylation; also abrogates STAT3 phosphorylation, nuclear translocation and inhibits the expression of downstream target genes. Delays tumor growth in a mouse xenograft model of human ovarian cancer. Orally active.
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Certificate of Analysis / Product Datasheet / Safety Data Sheet
Xu et al (2013) Discovery of a novel orally active small-molecule gp130 inhibitor for the treatment of ovarian cancer. Mol.Cancer Ther. 12 937. PMID: 23536726.
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