10Z-Hymenialdisine

Cat. No. 1532

10Z-Hymenialdisine C11H10BrN5O2 [82005-12-7]

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Alternative Name: SK&F 108752

Chemical Name: (4Z)-4-(2-Amino-1,5-dihydro-5-oxo-4H-imidazol-4-ylidene)-2-bromo-4,5,6,7-tetrahydropyrrolo[2,3-c]azepin-8(1H)-one

Biological Activity

Pan kinase inhibitor (IC50 values are 6, 10, 22, 28, 35, 40, 70, 80, 100, 470, 500, 600, 700 and 700 nM for MEK1, GSK-3β, Cdk1/cyclin B, Cdk5/p25, CK1, Cdk2/cyclin A, Cdk2/cyclin E, ASK-γ, Cdk3/cyclin E, Erk1, PKCγ, Cdk4/cyclin D1, Cdk6/cyclin D2 and PKCα respectively.) Inhibits NF-κB activation and blocks IL-8 production in U937 cells (IC50 values are 1-2 and 0.34-0.48 μM respectively).

Technical Data

M.Wt:
324.13
Formula:
C11H10BrN5O2
Solubility:
Soluble to 10 mM in DMSO
Purity:
>97 %
Storage:
Store at -20°C
CAS No:
82005-12-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Tasdemir et al (2002) Aldisine alkaloids from the Philippine sponge Stylissa massa are potent inhibitors of mitogen-activated protein kinase kinase-1 (MEK-1). J.Med.Chem. 45 529. PMID: 11784156.

Meijer et al (2000) Inhibition of cyclin-dependent kinases, GSK-3β and CK1 by hymenialdisine, a marine sponge constituent. Chem.Biol. 7 51. PMID: 10662688.

Breton and Chabot-Fletcher (1997) The natural product hymenialdisine inhibits interleukin-8 production in U937 cells by inhibition of nuclear factor-κB. J.Pharmacol.Exp.Ther. 282 459. PMID: 9223588.

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Keywords: 10Z-Hymenialdisine, supplier, SK&F108752, potent, pan, kinase, inhibitors, inhibits, CK1, Cdk, GSK-3beta, GSK-3b, cyclin, Erk1, MEK-1, MEK1, PKC, NF-kB, NF-kappaB, activation, IL-8, production, anti-inflammatory, Tocris Bioscience, MEK Inhibitor products

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