ML 179

Cat. No. 4957

ML 179 C21H25F3N4O2

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Chemical Name: 3-Cyclohexyl-6-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]-1H-pyrimidine-2,4-dione

Biological Activity

Selective liver receptor homolog 1 (LRH1, NR5A2) inverse agonist (IC50 = 320 nM and maximum efficacy of 64% repression). Exhibits >31-fold selectivity over SF1.

Technical Data

M.Wt:
422.44
Formula:
C21H25F3N4O2
Solubility:
Soluble to 50 mM in DMSO
Purity:
>99 %
Storage:
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Busby et al (2010) Discovery of inverse agonists for the liver receptor homologue-1 (LRH1; NR5A2). Probe Reports from the NIH Molecular Libraries Program . PMID: 23166964.

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Keywords: ML 179, supplier, ML179, Selective, inverse, agonists, agonism, liver, receptor, homolog-1, LRH1, Tocris Bioscience, Other Nuclear Receptor Antagonist products

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