UAMC 00039 dihydrochloride

Cat. No. 4954

UAMC 00039 dihydrochloride C16H24ClN3O.2HCl [697797-51-6]

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Chemical Name: (2S)-2-Amino-4-[[(4-chlorophenyl)methyl]amino]-1-(1-piperidinyl)-1-butanone dihydrochloride

Biological Activity

Potent inhibitor of dipeptidyl peptidase II (DPP-II) (IC50 = 0.48 nM). Exhibits selectivity for DPP-II against DPP-9, DPP-8 and DPP-IV (IC50 values are 78.6, 142 and 165 μM, respectively). Orally available.

Technical Data

Soluble to 100 mM in water and to 100 mM in DMSO
>98 %
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Van Goethem et al (2011) Structure-activity relationship studies on isoindoline inhibitors of dipeptidyl peptidases 8 and 9 (DPP8, DPP9): is DPP8-selectivity an attainable goal? J.Med.Chem. 54 5737. PMID: 21711053.

Maes et al (2007) Dipeptidyl peptidase 8/9-like activity in human leukocytes. J.Leukoc.Biol. 81 1252. PMID: 17287297.

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Keywords: UAMC 00039 dihydrochloride, supplier, UAMC00039, dihydrochloride, dipeptidyl, peptidase, II, DPP-II, 2, inhibitors, inhibits, selective, potent, proteases, Tocris Bioscience, Other Protease Inhibitor products

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