UAMC 00039 dihydrochloride
Cat. No. 4954
Chemical Name: (2S)-2-Amino-4-[[(4-chlorophenyl)me
Biological ActivityPotent inhibitor of dipeptidyl peptidase II (DPP-II) (IC50 = 0.48 nM). Exhibits selectivity for DPP-II against DPP-9, DPP-8 and DPP-IV (IC50 values are 78.6, 142 and 165 μM, respectively). Orally available.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Van Goethem et al (2011) Structure-activity relationship studies on isoindoline inhibitors of dipeptidyl peptidases 8 and 9 (DPP8, DPP9): is DPP8-selectivity an attainable goal? J.Med.Chem. 54 5737. PMID: 21711053.
Maes et al (2007) Dipeptidyl peptidase 8/9-like activity in human leukocytes. J.Leukoc.Biol. 81 1252. PMID: 17287297.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses UAMC 00039 dihydrochloride from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: UAMC 00039 dihydrochloride, supplier, UAMC00039, dihydrochloride, dipeptidyl, peptidase, II, DPP-II, 2, inhibitors, inhibits, selective, potent, proteases, Tocris Bioscience, Other Protease Inhibitor products
Find multiple products by catalog number
New Products in this Area
Potent 20S proteasome inhibitorDiprotin A
Dipeptidyl peptidase IV (DPP-IV) inhibitorAcein
High affinity angiotensin-converting enzyme (ACE) ligandTMI 1
Adam 17 (TACE) and MMP inhibitor; orally bioavailable
Follow Tocris on LinkedIn
Visit our LinkedIn page for the latest Tocris news, events and updates.