CHIR 99021 trihydrochloride

Cat. No. 4953

CHIR 99021 trihydrochloride C22H18Cl2N8.3HCl [1782235-14-6]

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Chemical Name: 6-[[2-[[4-(2,4-Dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)-2-pyrimidinyl]amino]ethyl]amino]-3-pyridinecarbonitrile trihydrochloride

Biological Activity

Hydrochloride salt of CHIR 99021 (Cat. No. 4423), a highly selective GSK-3 inhibitor.

External Portal Information

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of CHIR 99021 is reviewed on the chemical probes website.

Technical Data

M.Wt:
574.72
Formula:
C22H18Cl2N8.3HCl
Solubility:
Soluble to 25 mM in water and to 50 mM in DMSO
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
1782235-14-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Ye et al (2012) Pleiotropy of glycogen synthase kinase-3 inhibition by CHIR99021 promotes self-renewal of embyronic stem cells from refractory mouse strains. PLoS One 7 e35892. PMID: 22540008.

Pan et al (2011) AKT kinase activity is required for lithium to modulate mood-related behaviors in mice. Neuropsychopharmacology 36 1397. PMID: 21389981.

Ring et al (2003) Selective glycogen synthase kinase 3 inhibitors potentiate insulin activation of glucose transport and utilization in vitro and in vivo. Diabetes 52 588. PMID: 12606497.

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Keywords: CHIR 99021 trihydrochloride, supplier, CHIR99021, trihydrochloride, glycogen, synthase, kinase, 3, gsk-3, gsk-3a, gsk-3alpha, gsk-3α, gsk-3b, gsk-3beta, gsk-3β, inhibitors, inhibits, highly, selective, potent, Tocris Bioscience, Glycogen Synthase Kinase 3 Inhibitor products

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