SA 4503 dihydrochloride
Cat. No. 4951
Chemical Name: 1-[2-(3,4-Dimethoxyphenyl)ethyl]-4-
Biological ActivitySelective σ1 receptor agonist (IC50 = 17.4 nM). Exhibits selectivity for σ1 over σ2 receptors. Inhibits angiotensin II-induced cardiomyocyte hypertrophy in vitro and attenuates myocardial hypertrophy in vivo. Enhances brain plasticity and sensorimotor function in a rat model of experimental stroke.
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Tagashira et al (2013) Stimulation of s1-receptor restores abnormal mitochondrial Ca2+ mobilization and ATP production following cardiac hypertrophy. Biochim.Biophys.Acta 1830 3082. PMID: 23298811.
Ruscher et al (2011) The sigma-1 receptor enhances brain plasticity and functional recovery after experimental stroke. Brain 134 732. PMID: 21278085.
Lever et al (2006) σ1 and σ2 receptor binding affinity and selectivity of SA4503 and fluoroethyl SA4503. Synapse 59 350. PMID: 16463398.
Matsuno et al (1996) Binding properties of SA4503, a novel and selective sigma 1 receptor agonist. Eur.J.Pharmacol. 306 271. PMID: 8813641.
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