SA 4503 dihydrochloride

Cat. No. 4951

SA 4503 dihydrochloride C23H32N2O2.2HCl [165377-44-6]

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Chemical Name: 1-[2-(3,4-Dimethoxyphenyl)ethyl]-4-(3-phenylpropyl)-piperazine dihydrochloride

Biological Activity

Selective σ1 receptor agonist (IC50 = 17.4 nM). Exhibits selectivity for σ1 over σ2 receptors. Inhibits angiotensin II-induced cardiomyocyte hypertrophy in vitro and attenuates myocardial hypertrophy in vivo. Enhances brain plasticity and sensorimotor function in a rat model of experimental stroke.

Technical Data

Soluble to 100 mM in water and to 20 mM in DMSO
>98 %
Desiccate at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Tagashira et al (2013) Stimulation of s1-receptor restores abnormal mitochondrial Ca2+ mobilization and ATP production following cardiac hypertrophy. Biochim.Biophys.Acta 1830 3082. PMID: 23298811.

Ruscher et al (2011) The sigma-1 receptor enhances brain plasticity and functional recovery after experimental stroke. Brain 134 732. PMID: 21278085.

Lever et al (2006) σ1 and σ2 receptor binding affinity and selectivity of SA4503 and fluoroethyl SA4503. Synapse 59 350. PMID: 16463398.

Matsuno et al (1996) Binding properties of SA4503, a novel and selective sigma 1 receptor agonist. Eur.J.Pharmacol. 306 271. PMID: 8813641.

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Keywords: SA 4503 dihydrochloride, supplier, SA4503, dihydrochloride, selective, agonists, sigma1, receptor, σ1, Tocris Bioscience, σ1 Receptor Agonist products

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