Cat. No. 4950
Chemical Name: 4-Chloro-N-(6-chloro-3-pyridinyl)be
Biological ActivityKV7.2/7.3 activator (EC50 = 0.38 μM). Decreases neuronal excitability in CA1 hippocampal neurons. Exhibits anticonvulsive properties in amygdala-kindled rats, a model for complex partial seizures.
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Boehlen et al (2013) The new KCNQ2 activator 4-Chlor-N-(6-chlor-pyridin-3-yl)-benzamid displays anticonvulsant potential. Br.J.Pharmacol. 168 1182. PMID: 23176257.
Amato et al (2011) N-Pyridyl and Pyrimidine Benzamides as KCNQ2/Q3 Potassium Channel Openers for the Treatment of Epilepsy. ACS Med.Chem.Lett. 2 481.
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Keywords: ICA 110381, supplier, ICA110381, KV7.2/7.3, KV7.2, KV7.3, KV7, KCNQ2, KCNQ3, KCNQ2/3, potassium, channels, epilepsy, seizures, anticonvulsive, antoconvulsant, excitability, neuronal, neurons, Tocris Bioscience, Voltage-gated Potassium (KV) Channel Activator products
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