Cat. No. 4949
Chemical Name: (3S)-3-(5-Chloro-2-methoxyphenyl)-3
Biological ActivityPotassium channel modulator. Acts as a positive modulator at neuronal Kv7 channels and calcium-activated K+ channels (BKCa) in HEK293 cells. Displays negative modulatory activity at Kv7.1 channels (Ki = 3.7 μM) and GABAA receptors. Displays anxiolytic activity in vivo.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Jepps et al (2012) One man's side effect is another man's therapeutic opportunity: targeting Kv7 channels in smooth muscle disorders. Br.J.Pharmacol. 168 19. PMID: 22880633.
Hamashima et al (2005) Catalytic enantioselective fluorination of oxindoles. J.Am.Chem.Soc. 127 10164. PMID: 16028916.
Korsgaard et al (2005) Anxiolytic effects of Maxipost (BMS-204352) and retigabine via activation of neuronal Kv7 channels. J.Pharmacol.Exp.Ther. 314 282. PMID: 15814569.
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Keywords: MaxiPost, supplier, potassium, channels, neuronal, Kv7, calcium, activated, K+, BK, GABAA, receptors, R-enantiomer, anxiolytic, anxiety, anxiolytics, Kv7.1, Tocris Bioscience, Voltage-gated Potassium (KV) Channel Modulator products
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