Cat. No. 4945
Alternative Names: LDN 193719, 1lWY, VU0469381
Chemical Name: 5-[6-(4-Methoxyphenyl)pyrazolo[1,5-
Biological ActivityPotent and selective ALK2 and ALK1 inhibitor (IC50 values are 32 and 46 nM, respectively); displays >200 fold selectivity over ALK3 and ALK6 and >400 fold selectivity over VEGF2. Exhibits no activity at ALK4, ALK5 or in a panel of related kinases. Inhibits BMP4 signaling in a functional assay (IC50 = 152 nM).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Engers et al (2013) Synthesis and structure-activity relationships of a novel and selective bone morphogenetic protein receptor (BMP) inhibitor derived from the pyrazolo[1.5-a]pyrimidine scaffold of dorsomorphin: the discovery of ML347 as an ALK2 versus ALK3 selective MLPCN probe. Bioorg Med Chem Lett. 23 3248. PMID: 23639540.
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Citations are publications that use Tocris products. Selected citations for ML 347 include:
Varadaraj et al (2015) Epigenetic Regulation of GDF2 Suppresses Anoikis in Ovarian and Breast Epithelia. Neoplasia 17 826. PMID: 26678910.
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Keywords: ML 347, supplier, ML347, Potent, selective, ALK1, ALK2, BMP, activin, receptor, like, kinase, Bone, morphogenetic, proteins, inhibitors, inhibits, Tocris Bioscience, BMP and Other Activin Receptor Inhibitor products
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