Cat. No. 4942
Alternative Name: NK-104
Chemical Name: (3R,5S,6E)-7-[2-Cyclopropyl-4-(4-fl
Biological ActivitySynthetic inhibitor of HMG-CoA reductase (Ki = 1.7 nM). Lowers low-density lipoprotein (LDL) cholesterol levels. Displays minimal metabolism by cytochrome P450 enzymes, with little involvement of CYP3A4. Shown to improve cardiac function and survival in a rat model of hypertensive heart failure.
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Saka et al (2006) Pitavastatin improves cardiac function and survival in association with suppression of the myocardial endothelin system in a rat model of hypertensive heart failure. J.Cardiovasc.Pharmacol. 47 770. PMID: 16810078.
Mukhtar et al (2005) Pitavastatin. Int.J.Clin.Pract. 59 239. PMID: 15854203.
Aoki et al (1997) Pharmacological profile of a novel synthetic inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A reductase. Arzneimittelforschung. 47 904. PMID: 9296275.
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Keywords: Pitavastatin calcium, supplier, NK-104, HMG, CoA, reductase, inhibitors, inhibits, synthetic, statins, Tocris Bioscience, HMG-CoA Reductase Inhibitor products
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