Pitavastatin calcium

Cat. No. 4942

Pitavastatin calcium C25H23FNO4.0.5Ca [147526-32-7]

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Alternative Name: NK-104

Chemical Name: (3R,5S,6E)-7-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-3,5-dihydroxy-6-heptenoic acid hemicalcium salt

Biological Activity

Synthetic inhibitor of HMG-CoA reductase (Ki = 1.7 nM). Lowers low-density lipoprotein (LDL) cholesterol levels. Displays minimal metabolism by cytochrome P450 enzymes, with little involvement of CYP3A4. Shown to improve cardiac function and survival in a rat model of hypertensive heart failure.

Technical Data

M.Wt:
440.5
Formula:
C25H23FNO4.0.5Ca
Solubility:
Soluble to 100 mM in DMSO
Purity:
>99 %
Storage:
Desiccate at RT
CAS No:
147526-32-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Saka et al (2006) Pitavastatin improves cardiac function and survival in association with suppression of the myocardial endothelin system in a rat model of hypertensive heart failure. J.Cardiovasc.Pharmacol. 47 770. PMID: 16810078.

Mukhtar et al (2005) Pitavastatin. Int.J.Clin.Pract. 59 239. PMID: 15854203.

Aoki et al (1997) Pharmacological profile of a novel synthetic inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A reductase. Arzneimittelforschung. 47 904. PMID: 9296275.

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Keywords: Pitavastatin calcium, supplier, NK-104, HMG, CoA, reductase, inhibitors, inhibits, synthetic, statins, Tocris Bioscience, HMG-CoA Reductase Inhibitor products

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