Sulfasalazine

Cat. No. 4935

Sulfasalazine C18H14N4O5S [599-79-1]

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Chemical Name: 5-[[4-(2-Pyridylsulfamoyl)phenyl]azo]salicylic acid

Biological Activity

Inhibitor of NF-κB activation. Inhibits in vitro growth of the human pancreatic cancer cell lines MIA PaCa-2 and PANC-1, and induces apoptosis in glioblastoma cell lines. Also inhibits the cystine-glutamate antiporter, system Xc (SXC). Anti-inflammatory.

Technical Data

M.Wt:
398.39
Formula:
C18H14N4O5S
Solubility:
Soluble to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at RT
CAS No:
599-79-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

Sontheimer and Bridges (2012) Sulfasalazine for brain cancer fits. Expert Opin.Invest.Drugs 21 575. PMID: 22404218.

Lo et al (2010) Potential use fo the anti-inflammatory drug, sulfasalazine, for targeted therapy of pancreatic cancer. Curr.Oncol. 17 9. PMID: 20567622.

Robe et al (2004) In vitro and in vivo activity of the nuclear factor-κB inhbitor sulfasalazine in human glioblastomas. Clin.Cancer Res. 10 5595. PMID: 15328202.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Sulfasalazine include:

Yeligar et al (2009) Ethanol augments RANTES/CCL5 expression in rat liver sinusoidal endothelial cells and human endothelial cells via activation of NF-kappa B, HIF-1 alpha, and AP-1. J Immunol 183 5964. PMID: 19828633.

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Keywords: Sulfasalazine, supplier, antirheumatic, antiinflammatories, antiinflammatory, arthritis, system, XC, SXC, cysteine-glutamate, antiporters, NF-kappaB, NF-kB, NF-κB, inhibitors, inhibits, Tocris Bioscience, NF-κB and IκB Inhibitor products

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