MA 2029

Cat. No. 4934

MA 2029 C31H45FN4O4 [287206-61-5]

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Chemical Name: 4-Fluoro-N-methyl-L-phenylalanyl-N-methyl-L-valyl-3-(1,1-dimethylethyl)-N-ethyl-L-tyrosinamide

Biological Activity

Potent and selective, competitive motilin receptor antagonist (IC50 = 4.9 nM). Selective for the motilin receptor over a range of other receptors and ion channels. Inhibits motilin-induced duodenal muscle contractions in vitro. Also inhibits motilin-induced colonic and abdominal contractions in vivo. Orally active.

Technical Data

M.Wt:
556.71
Formula:
C31H45FN4O4
Solubility:
Soluble to 20 mM in 1eq. HCl and to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
287206-61-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Sudo et al (2008) Oral administration of MA-2029, a novel selective and competitive motilin receptor antagonist, inhibits motilin-induced intestinal contractions and visceral pain in rabbits. Eur.J.Pharmacol. 581 296. PMID: 18164286.

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Keywords: MA 2029, supplier, MA2029, potent, selective, competitive, motilin, receptors, antagonists, Tocris Bioscience, Motilin Receptor Antagonist products

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