OXF BD 02

Cat. No. 4928

OXF BD 02 C18H17NO3 [1429129-68-9]

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Chemical Name: 3-(3,5-Dimethyl-4-isoxazolyl)-5-hydroxy-α-phenylbenzenemethanol

Biological Activity

Selective inhibitor of the first bromodomain of BRD4 (BRD4(1)) (IC50 = 382 nM). Exhibits 2-3-fold selectivity for BRD4(1) over the CBP bromodomain and has little affinity for a range of other bromodomains. Reduces viability of lung adenocarcinoma cell lines and attenuates proliferation of MV-4-11 leukemia cells. Cell permeable.

Licensing Information

Sold with the agreement of the University of Oxford

Technical Data

M.Wt:
295.33
Formula:
C18H17NO3
Solubility:
Soluble to 100 mM in DMSO and to 10 mM in ethanol with gentle warming
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
1429129-68-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Hewings et al (2013) Optimization of 3,5-dimethylisoxazole derivatives as potent bromodomain ligands. J.Med.Chem. 56 3217. PMID: 23517011.

Hewings et al (2011) 3,5-dimethylisoxazoles act as acetyl-lysine-mimetic bromodomain ligands. J.Med.Chem. 54 6761. PMID: 21851057.

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Keywords: OXF BD 02, supplier, OXFBD02, selective, bromodomains, BRD, BRD4(1), inhibitors, cell, permeable, antiproliferative, inhibits, Tocris Bioscience, Bromodomain Inhibitor products

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