AS 1892802

Cat. No. 4927

AS 1892802 C20H19N3O2 [928320-12-1]

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Chemical Name: N-[(1S)-2-Hydroxy-1-phenylethyl]-N'-[4-(4-pyridinyl)phenyl]-urea

Biological Activity

Potent, ATP-competitive ROCK inhibitor (IC50 values are 52, 57 and 122 nM for human ROCK2, rat ROCK2 and human ROCK1 respectively by ELISA); also inhibits PKAC-α and PRKX (IC50 values are 200 and 325 nM respectively). Exhibits analgesic effects in rat models of inflammatory (AIA) and noninflammatory (MIA) arthritic pain. Orally bioavailable.

Technical Data

M.Wt:
333.38
Formula:
C20H19N3O2
Solubility:
Soluble to 100 mM in DMSO and to 25 mM in ethanol
Purity:
>99 %
Storage:
Store at RT
CAS No:
928320-12-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

Li et al (2012) Fragment-based and structure-guided discovery and optimization of Rho kinase inhibitors. J.Med.Chem. 55 2474. PMID: 22272748.

Yoshimi et al (2010) Antinociceptive effects of AS1892802, a novel Rho kinase inhibitor, in rat models of inflammatory and noninflammatory arthritis. J.Pharmacol.Exp.Ther. 334 955. PMID: 20534789.

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Keywords: AS 1892802, supplier, AS1892802, rho, kinases, ROCK1, ROCK2, potent, selective, inhibitors, inhibits, ATP, competitive, pain, analgesics, analgesia, chronic, arthritis, antiinflammatory, MIA, AIA, orally, bioavailable, Tocris Bioscience, Rho-Kinases Inhibitor products

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