Lovastatin

Cat. No. 1530

Lovastatin C24H36O5 [75330-75-5]

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Alternative Name: Mevinolin

Chemical Name: (2S)-(1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-Hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl-2-methyl butanoate

Biological Activity

Potent, competitive inhibitor of HMG-CoA reductase (Ki = 0.6 nM) therefore decreases cholesterol biosynthesis, in vitro and in vivo. Decreases CDK2, 4, 6 and cyclin E levels and induces G1 arrest and apoptosis in tumor cell lines in vitro. Inactive lactam prodrug of lovastatin hydroxy acid, naturally bioactivated in vivo following oral administration.

Technical Data

M.Wt:
404.54
Formula:
C24H36O5
Solubility:
Soluble to 50 mM in ethanol with gentle warming and to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at RT
CAS No:
75330-75-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Park et al (1999) Lovastatin-induced inhibition of HL-60 cell proliferation via cell cycle arrest and apoptosis. Anticancer Res. 19 3133. PMID: 10652602.

Alberts (1988) Discovery, biochemistry and biology of lovastatin. Am.J.Cardiol. 62 10J. PMID: 3055919.

Alberts et al (1980) Mevinolin: a highly potent competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase and a cholesterol-lowering agent. Proc.Natl.Acad.Sci.U.S.A. 77 3957. PMID: 6933445.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Lovastatin include:

Ibrahim et al (2015) The Effects of Targeted Deliveries of Lovastatin and Tocotrienol on Ossification-Related Gene Expressions in Fracture Healing in an Osteoporosis Rat Model. Int J Environ Res Public Health 12 12958. PMID: 26501302.

Saqcena et al (2015) Apoptotic effects of high-dose rapamycin occur in S-phase of the cell cycle. Oncotarget 14 2285. PMID: 25945415.

Buchovecky et al (2013) A suppressor screen in Mecp2 mutant mice implicates cholesterol metabolism in Rett syndrome. Nat Genet 45 1013. PMID: 23892605.

Vainio et al (2011) Phospholipase PLA2G7, associated with aggressive prostate cancer, promotes prostate cancer cell migration and invasion and is inhibited by statins. J Neurosci 2 1176. PMID: 22202492.

Do you know of a great paper that uses Lovastatin from Tocris? If so please let us know.show all ▼show less ▲

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Keywords: Lovastatin, supplier, HMG-CoA, reductases, inhibitors, inhibits, Tocris Bioscience, HMG-CoA Reductase Inhibitor products

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