Cat. No. 1530
Alternative Name: Mevinolin
Chemical Name: (2S)-(1S,3R,7S,8S,8aR)-1,2,3,7,8,8a
Biological ActivityPotent, competitive inhibitor of HMG-CoA reductase (Ki = 0.6 nM) therefore decreases cholesterol biosynthesis, in vitro and in vivo. Decreases CDK2, 4, 6 and cyclin E levels and induces G1 arrest and apoptosis in tumor cell lines in vitro. Inactive lactam prodrug of lovastatin hydroxy acid, naturally bioactivated in vivo following oral administration.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Park et al (1999) Lovastatin-induced inhibition of HL-60 cell proliferation via cell cycle arrest and apoptosis. Anticancer Res. 19 3133. PMID: 10652602.
Alberts (1988) Discovery, biochemistry and biology of lovastatin. Am.J.Cardiol. 62 10J. PMID: 3055919.
Alberts et al (1980) Mevinolin: a highly potent competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase and a cholesterol-lowering agent. Proc.Natl.Acad.Sci.U.S.A. 77 3957. PMID: 6933445.
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Citations are publications that use Tocris products. Selected citations for Lovastatin include:
Ibrahim et al (2015) The Effects of Targeted Deliveries of Lovastatin and Tocotrienol on Ossification-Related Gene Expressions in Fracture Healing in an Osteoporosis Rat Model. Int J Environ Res Public Health 12 12958. PMID: 26501302.
Saqcena et al (2015) Apoptotic effects of high-dose rapamycin occur in S-phase of the cell cycle. Oncotarget 14 2285. PMID: 25945415.
Buchovecky et al (2013) A suppressor screen in Mecp2 mutant mice implicates cholesterol metabolism in Rett syndrome. Nat Genet 45 1013. PMID: 23892605.
Vainio et al (2011) Phospholipase PLA2G7, associated with aggressive prostate cancer, promotes prostate cancer cell migration and invasion and is inhibited by statins. J Neurosci 2 1176. PMID: 22202492.
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Keywords: Lovastatin, supplier, HMG-CoA, reductases, inhibitors, inhibits, Tocris Bioscience, HMG-CoA Reductase Inhibitor products
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