Cat. No. 4922
Biological ActivityPotent P2X3 receptor modulator (IC50 = 12 nM). Exhibits negligible effects on P2X2 and P2X2/3. Demonstrates antinociceptive properties in an animal model of inflammatory pain.
(Modifications: Disulfide bridge: 3-16,10-21,15-32, 23-30)
(Modifications: Lys-35 = C-terminal amide)
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Kabanova et al (2012) Modulation of P2X3 receptors by spider toxins. Biochim.Biophys.Acta. 1818 2868. PMID: 22842000.
Grishin et al (2010) Novel peptide from spider venom inhibits P2X3 receptors and inflammatory pain. Ann.Neurol. 67 680. PMID: 20437566.
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Keywords: Purotoxin 1, supplier, P2X3, P2X, purinergics, receptors, modulators, antinociceptive, pain, inflammatory, Tocris Bioscience, Purinergic (P2X) Receptor Modulator products
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March 18 - 22, 2017
Little Rock, ARK, USA