Purotoxin 1

Cat. No. 4922

Purotoxin 1 Gly-Tyr-Cys-Ala-Glu-Lys-Gly-Ile-Arg-Cys-Asp-Asp-Ile-His-Cys-Cys-Thr-Gly-Leu-Lys-Cys-Lys-Cys-Asn-Ala-Ser-Gly-Tyr-Asn-Cys-Val-Cys-Arg-Lys-Lys-NH2

Price and Availability

For Purotoxin 1 pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Biological Activity

Potent P2X3 receptor modulator (IC50 = 12 nM). Exhibits negligible effects on P2X2 and P2X2/3. Demonstrates antinociceptive properties in an animal model of inflammatory pain.

Technical Data

M.Wt:
3835.47
Formula:
C155H249N51O47S8
Sequence:
GYCAEKGIRCDDIHCCTGLKCKCNASGYNCVCRKK

(Modifications: Disulfide bridge: 3-16,10-21,15-32, 23-30)

(Modifications: Lys-35 = C-terminal amide)

Solubility:
Soluble to 1 mg/ml in water
Storage:
Store at -20°C
CAS No:
1396322-38-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Kabanova et al (2012) Modulation of P2X3 receptors by spider toxins. Biochim.Biophys.Acta. 1818 2868. PMID: 22842000.

Grishin et al (2010) Novel peptide from spider venom inhibits P2X3 receptors and inflammatory pain. Ann.Neurol. 67 680. PMID: 20437566.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products.

Do you know of a great paper that uses Purotoxin 1 from Tocris? If so please let us know.

View Related Products by Product Action

Keywords: Purotoxin 1, supplier, P2X3, P2X, purinergics, receptors, modulators, antinociceptive, pain, inflammatory, Tocris Bioscience, Purinergic (P2X) Receptor Modulator products

Quick Order

Find multiple products by catalog number

divider line

Pain Research Product Guide

Pain Research Product Guide

Our Pain guide highlights over 280 products for Pain research. Request copy or view PDF today.

divider line

Cardiovascular Research Product Guide

Cardiovascular Research Product Guide

Our Cardiovascular Guide highlights over 250 products for cardiovascular research. Request copy or view PDF today.

divider line

P2 Receptors Review

Written by Kenneth Jacobson

P2X and P2Y Receptors Scientific Review

Our Purine Receptor review gives an overview of the subtypes and structures of the P2 receptor family, and the pharmacological ligands used to study them. Request copy or view PDF today.

divider line

Peripheral Sensitization

Written by Grant D. Nicol and Michael R. Vasko

Pain Life Science Poster

Our Peripheral Sensitization poster gives a summary of the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. Request copy or view PDF today.

divider line

LinkedIn Updates

Follow Tocris on LinkedIn

Follow us on LinkedIn!

Visit our LinkedIn page for the latest Tocris news, events and updates.