Purotoxin 1

Cat. No. 4922

Purotoxin 1 Gly-Tyr-Cys-Ala-Glu-Lys-Gly-Ile-Arg-Cys-Asp-Asp-Ile-His-Cys-Cys-Thr-Gly-Leu-Lys-Cys-Lys-Cys-Asn-Ala-Ser-Gly-Tyr-Asn-Cys-Val-Cys-Arg-Lys-Lys-NH2

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Biological Activity

Potent P2X3 receptor modulator (IC50 = 12 nM). Exhibits negligible effects on P2X2 and P2X2/3. Demonstrates antinociceptive properties in an animal model of inflammatory pain.

Technical Data


(Modifications: Disulfide bridge: 3-16,10-21,15-32, 23-30)

(Modifications: Lys-35 = C-terminal amide)

Soluble to 1 mg/ml in water
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Kabanova et al (2012) Modulation of P2X3 receptors by spider toxins. Biochim.Biophys.Acta. 1818 2868. PMID: 22842000.

Grishin et al (2010) Novel peptide from spider venom inhibits P2X3 receptors and inflammatory pain. Ann.Neurol. 67 680. PMID: 20437566.

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Citations are publications that use Tocris products.

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Keywords: Purotoxin 1, supplier, P2X3, P2X, purinergics, receptors, modulators, antinociceptive, pain, inflammatory, venoms, Tocris Bioscience, Purinergic (P2X) Receptor Modulator products

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