Methoxy-X04

Cat. No. 4920

Methoxy-X04 C23H20O3 [863918-78-9]

Price and Availability

For Methoxy-X04 pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: 4,4'-[(2-methoxy-1,4-phenylene)di-(1E)-2,1-ethenediyl]bisphenol

Biological Activity

Fluorescent amyloid β (Aβ) probe for the detection and quantification of plaques, tangles and cerebrovascular amyloid. Displays high in vitro binding affinity (Ki = 26.8 nM); binds selectively to fibrillar β-sheet deposits. Brain penetrant.

Technical Data

M.Wt:
344.4
Formula:
C23H20O3
Solubility:
Soluble to 100 mM in DMSO and to 20 mM in ethanol
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
863918-78-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Yamanaka et al (2012) PPARγ/RXRα-induced and CD36-mediated microglial amyloid-β phagocytosis results in cognitive improvement in amyloid precursor protein/presenilin 1 mice. J.Neurosci. 32 17321. PMID: 23197723.

Bolmont et al (2008) Dynamics of the microglial/amyloid interaction indicate a role in plaque maintenance. J.Neurosci. 28 4283. PMID: 18417708.

Klunk et al (2002) Imaging Aβ plaques in living transgenic mice with multiphoton microscopy and methoxy-X04, a systemically administered Congo red derivative. J.Neuropathol.Exp.Neurol. 61 797. PMID: 12230326.

If you know of a relevant reference for Methoxy-X04 please let us know.

Citations are publications that use Tocris products. Selected citations for Methoxy-X04 include:

Fu et al (2016) IL-33 ameliorates Alzheimer's disease-like pathology and cognitive decline. Elife 113 E2705. PMID: 27091974.

Do you know of a great paper that uses Methoxy-X04 from Tocris? If so please let us know.

View Related Products by Product Action

Keywords: Methoxy-X04, supplier, amyloid, beta, fluorescent, probes, detection, alzheimers, disease, brain, penetrant, blood, brain, barrier, permeable, high, affinity, amyloidbeta, amyloidb, amyloidβ, Tocris Bioscience, Fluorescent Probe products

Quick Order

Find multiple products by catalog number

divider line

New Product Guide

Spring/Summer 2017

New Product Guide (Spring/Summer 2017)

Our New Product guide highlights over 130 new products added in the first half of 2017. View PDF today.

divider line

New Products in this Area

PA Janelia Fluor® 646, SE

Photoactivatable cell permeable fluorescent dye; supplied as NHS ester

PA Janelia Fluor® 549, SE

Photoactivatable cell permeable fluorescent dye; supplied as NHS ester

Cyanine 7, SE

Near-infrared fluorescent dye for labeling of amines

Cyanine 3, SE

Orange fluorescent dye for labeling of amines

FFN 200 dihydrochloride

Selective fluorescent VMAT2 substrate

Janelia Fluor® 646, SE

Cell permeable fluorescent dye; supplied as NHS ester

Janelia Fluor® 549, SE

Cell permeable fluorescent dye; supplied as NHS ester

Sign-up for new product e-alerts
divider line

LinkedIn Updates

Follow Tocris on LinkedIn

Follow us on LinkedIn!

Visit our LinkedIn page for the latest Tocris news, events and updates.