Cat. No. 4920
Chemical Name: 4,4'-[(2-methoxy-1,4-phenylene)di-(1
Biological ActivityFluorescent amyloid β (Aβ) probe for the detection and quantification of plaques, tangles and cerebrovascular amyloid. Displays high in vitro binding affinity (Ki = 26.8 nM); binds selectively to fibrillar β-sheet deposits. Brain penetrant.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Yamanaka et al (2012) PPARγ/RXRα-induced and CD36-mediated microglial amyloid-β phagocytosis results in cognitive improvement in amyloid precursor protein/presenilin 1 mice. J.Neurosci. 32 17321. PMID: 23197723.
Bolmont et al (2008) Dynamics of the microglial/amyloid interaction indicate a role in plaque maintenance. J.Neurosci. 28 4283. PMID: 18417708.
Klunk et al (2002) Imaging Aβ plaques in living transgenic mice with multiphoton microscopy and methoxy-X04, a systemically administered Congo red derivative. J.Neuropathol.Exp.Neurol. 61 797. PMID: 12230326.
If you know of a relevant reference for Methoxy-X04 please let us know.
Citations are publications that use Tocris products. Selected citations for Methoxy-X04 include:
Fu et al (2016) IL-33 ameliorates Alzheimer's disease-like pathology and cognitive decline. Elife 113 E2705. PMID: 27091974.
Do you know of a great paper that uses Methoxy-X04 from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: Methoxy-X04, supplier, amyloid, beta, fluorescent, probes, detection, alzheimers, disease, brain, penetrant, blood, brain, barrier, permeable, high, affinity, amyloidbeta, amyloidb, amyloidβ, Tocris Bioscience, Amyloid β Peptide products
Find multiple products by catalog number
New Products in this Area
RAD51 recombinase inhibitorPCNA I1
PCNA inhibitorPladienolide B
mRNA splicing inhibitor; antitumorLin28 1632
RNA binding protein Lin28 inhibitor; promotes mESC differentiation; also bromodomain inhibitor
June 14 - 17, 2017
Boston, MA, USA