Methoxy-X04

Cat. No. 4920

Methoxy-X04 C23H20O3 [863918-78-9]

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Chemical Name: 4,4'-[(2-methoxy-1,4-phenylene)di-(1E)-2,1-ethenediyl]bisphenol

Biological Activity

Fluorescent amyloid β (Aβ) probe for the detection and quantification of plaques, tangles and cerebrovascular amyloid. Displays high in vitro binding affinity (Ki = 26.8 nM); binds selectively to fibrillar β-sheet deposits. Brain penetrant.

Technical Data

M.Wt:
344.4
Formula:
C23H20O3
Solubility:
Soluble to 100 mM in DMSO and to 20 mM in ethanol
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
863918-78-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Yamanaka et al (2012) PPARγ/RXRα-induced and CD36-mediated microglial amyloid-β phagocytosis results in cognitive improvement in amyloid precursor protein/presenilin 1 mice. J.Neurosci. 32 17321. PMID: 23197723.

Bolmont et al (2008) Dynamics of the microglial/amyloid interaction indicate a role in plaque maintenance. J.Neurosci. 28 4283. PMID: 18417708.

Klunk et al (2002) Imaging Aβ plaques in living transgenic mice with multiphoton microscopy and methoxy-X04, a systemically administered Congo red derivative. J.Neuropathol.Exp.Neurol. 61 797. PMID: 12230326.

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Citations are publications that use Tocris products. Selected citations for Methoxy-X04 include:

Fu et al (2016) IL-33 ameliorates Alzheimer's disease-like pathology and cognitive decline. Elife 113 E2705. PMID: 27091974.

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Keywords: Methoxy-X04, supplier, amyloid, beta, fluorescent, probes, detection, alzheimers, disease, brain, penetrant, blood, brain, barrier, permeable, high, affinity, amyloidbeta, amyloidb, amyloidβ, Tocris Bioscience, Amyloid β Peptide products

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