PG 106

Cat. No. 4919

PG 106 Ac-Nle-cyclo(Asp-beta-Ala-D-2-Nal-Arg-Trp-Lys)-NH2

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Biological Activity

Selective hMC3 receptor antagonist (IC50 = 210 nM). Exhibits no activity at hMC4 receptors and hMC5 receptors.

Technical Data

M.Wt:
1008.19
Formula:
C51H69N13O9
Sequence:
XDXXRWK

(Modifications: X-1 = Ac-Nle, X-3 = beta-Ala, X-4 = D-2-Nal, Lys-7 = C-terminal amide, Asp-2, Lys-7, Cyclized)

Solubility:
Soluble to 1 mg/ml in 25% ethanol / water
Storage:
Store at -20°C
CAS No:
944111-22-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Grieco et al (2007) Further structure-activity studies of lactam derivatives of MT-II and SHU-9119: their activity and selectivity at human melanocortin receptors 3, 4, and 5. Peptides. 28 1191. PMID: 17482720.

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Citations are publications that use Tocris products.

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Keywords: PG 106, supplier, PG106, MC3, melanocortin, receptors, antagonists, Tocris Bioscience, Melanocortin (MC) Receptor Antagonist products

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