GSA 10

Cat. No. 4918

GSA 10 C26H30N2O5 [300833-95-8]

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Chemical Name: 4-[[(1-Hexyl-1,2-dihydro-2-oxo-3-quinolinyl)carbonyl]amino]benzoic acid propyl ester

Biological Activity

Smoothened (Smo) receptor agonist (EC50 = 1.2 μM). Does not recognize the classic cyclopamine (Cat. No. 1623) binding site. Does not promote Smo translocation to the primary cilium; is strongly potentiated by forskolin and cholera toxin. Promotes differentiation of multipotent mesenchymal progenitor cells into osteoblasts.

Technical Data

M.Wt:
450.53
Formula:
C26H30N2O5
Solubility:
Soluble to 5 mM in DMSO with gentle warming
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
300833-95-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

Gorojankina et al (2013) Discovery, molecular and pharmacological characterization of GSA-10, a novel small-molecule positive modulator of Smoothened. Mol.Pharmacol. 83 1020. PMID: 23448715.

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Keywords: GSA 10, supplier, GSA10, Smoothened, Smo, receptors, agonists, differentiation, multipotent, mesenchymal, progenitor, cells, osteoblasts, osteogenic, Tocris Bioscience, Smoothened Receptor Agonist products

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