Cat. No. 4916
Chemical Name: 1-Methyl-[1-[4-(4-trifluoromethoxy)
Biological ActivityPotent NaV1.8 inhibitor (IC50 = 53 nM for human NaV1.8 channel). Exhibits selectivity for hNaV1.8 over hNaV1.6, hNaV1.7, hNaV1.1, hNaV1.2 and hNaV1.5 (IC50 values are 4.2, 7.0, 11, 16 and 27 μM respectively). Orally bioavailable.
Licensing InformationSold for research purposes under agreement from Pfizer Inc.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Bagal et al (2013) Discovery of selective NaV1.8 modulators for the treatment of chronic pain. Abstract. 4th RSC/SCI Symp. on Ion Channels as Ther. Targ.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses PF 04885614 from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: PF 04885614, supplier, PF04885614, NaV1.8, voltage, gated, sodium, channel, inhibitors, inhibits, potent, selective, in, vivo, efficacy, antinociceptive, analgesic, Tocris Bioscience, Voltage-gated Sodium (NaV) Channel Blocker products