Cat. No. 4911
Alternative Name: Leiuropeptide II
Biological ActivityVery high affinity ClC-2 blocker (apparent KD ~ 50 pM). Slows ClC-2 activation and inhibits slow-gating but does not inhibit open ClC-2 channels. Selective for ClC-2 over other ClC family members (ClC-0, ClC-1, ClC-3 and ClC-4), CFTR, GABAC, CaCC and KV1.2.
(Modifications: Disulfide bridge: 3-19, 6-24, 10-26)
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Schiffhauer et al (2013) Dual activation of CFTR and CLCN2 by lubiprostone in murine nasal epithelia. Am.J.Physiol.Lung Cell Mol.Physiol. 304 L324. PMID: 23316067.
Thompson et al (2009) Isolation and characterization of a high affinity peptide inhibitor of ClC-2 chloride channels. J.Biol.Chem. 284 26051. PMID: 19574231.
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Citations are publications that use Tocris products.
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Keywords: GaTx2, supplier, high, affinity, ClC-2, blockers, chloride, channels, selective, slow, gating, venoms, Tocris Bioscience, Other Chloride Channel Blocker products