GaTx2

Cat. No. 4911

GaTx2 Val-Ser-Cys-Glu-Asp-Cys-Pro-Asp-His-Cys-Ser-Thr-Glu-Lys-Ala-Arg-Ala-Lys-Cys-Asp-Asn-Asp-Lys-Cys-Val-Cys-Glu-Pro-Ile

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Alternative Name: Leiuropeptide II

Biological Activity

Very high affinity ClC-2 blocker (apparent KD ~ 50 pM). Slows ClC-2 activation and inhibits slow-gating but does not inhibit open ClC-2 channels. Selective for ClC-2 over other ClC family members (ClC-0, ClC-1, ClC-3 and ClC-4), CFTR, GABAC, CaCC and KV1.2.

Technical Data

M.Wt:
3192.54
Formula:
C125H199N39O47S6
Sequence:
VSCEDCPDHCSTQKARAKCDNDKCVCEPI

(Modifications: Disulfide bridge: 3-19, 6-24, 10-26)

Solubility:
Soluble to 1 mg/ml in water
Storage:
Store at -20°C
CAS No:
194665-85-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

Schiffhauer et al (2013) Dual activation of CFTR and CLCN2 by lubiprostone in murine nasal epithelia. Am.J.Physiol.Lung Cell Mol.Physiol. 304 L324. PMID: 23316067.

Thompson et al (2009) Isolation and characterization of a high affinity peptide inhibitor of ClC-2 chloride channels. J.Biol.Chem. 284 26051. PMID: 19574231.

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Keywords: GaTx2, supplier, high, affinity, ClC-2, blockers, chloride, channels, selective, slow, gating, venoms, Tocris Bioscience, Other Chloride Channel Blocker products

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