Cat. No. 4911

GaTx2 Val-Ser-Cys-Glu-Asp-Cys-Pro-Asp-His-Cys-Ser-Thr-Glu-Lys-Ala-Arg-Ala-Lys-Cys-Asp-Asn-Asp-Lys-Cys-Val-Cys-Glu-Pro-Ile

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Alternative Name: Leiuropeptide II

Biological Activity

Very high affinity ClC-2 blocker (apparent KD ~ 50 pM). Slows ClC-2 activation and inhibits slow-gating but does not inhibit open ClC-2 channels. Selective for ClC-2 over other ClC family members (ClC-0, ClC-1, ClC-3 and ClC-4), CFTR, GABAC, CaCC and KV1.2.

Technical Data


(Modifications: Disulfide bridge: 3-19, 6-24, 10-26)

Soluble to 1 mg/ml in water
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Schiffhauer et al (2013) Dual activation of CFTR and CLCN2 by lubiprostone in murine nasal epithelia. Am.J.Physiol.Lung Cell Mol.Physiol. 304 L324. PMID: 23316067.

Thompson et al (2009) Isolation and characterization of a high affinity peptide inhibitor of ClC-2 chloride channels. J.Biol.Chem. 284 26051. PMID: 19574231.

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Keywords: GaTx2, supplier, high, affinity, ClC-2, blockers, chloride, channels, selective, slow, gating, Tocris Bioscience, Chloride Channel Blocker products

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