GNF 5

Cat. No. 4908

GNF 5 C20H17F3N4O3 [778277-15-9]

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Chemical Name: N-(2-Hydroxyethyl)-3-[6-[[4-(trifluoromethoxy)phenyl]amino]-4-pyrimidinyl]benzamide

Biological Activity

Selective, non-ATP competitive allosteric inhibitor of Bcr-Abl (IC50 = 220 nM for wild-type Abl). Binds the myristate-binding site of Abl. Acts in combination with nilotinib to inhibit T315I Bcr-Abl in vitro and in vivo. Analog of GNF 2 (Cat. No. 4399).

External Portal Information

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of GNF 5 is reviewed on the chemical probes website.

Technical Data

M.Wt:
418.37
Formula:
C20H17F3N4O3
Solubility:
Soluble to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
778277-15-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Iacob et al (2011) Allosteric interactions between the myristate- and ATP-site of the Abl kinase. PLoS One 6 e15929. PMID: 21264348.

Deng et al (2010) Expanding the diversity of allosteric Bcr-Abl inhibitors. J.Med.Chem. 53 6934. PMID: 20828158.

Zhang et al (2010) Targeting Bcr-Abl by combining allosteric with ATP-binding-site inhibitors. Nature 463 501. PMID: 20072125.

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Citations are publications that use Tocris products.

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Keywords: GNF 5, supplier, GNF5, Bcr-Abl, kinase, allosteric, inhbitors, inhibits, selective, bcrabl, bcr, abl, fusion, philadelphia, chromosome, chronic, myeloid, leukemia, leukaemia, CML, allosteric, Tocris Bioscience, Abl Kinase Inhibitor products

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