Cat. No. 4908
Chemical Name: N-(2-Hydroxyethyl)-3-[6-[[4-(triflu
Biological ActivitySelective, non-ATP competitive allosteric inhibitor of Bcr-Abl (IC50 = 220 nM for wild-type Abl). Binds the myristate-binding site of Abl. Acts in combination with nilotinib to inhibit T315I Bcr-Abl in vitro and in vivo. Analog of GNF 2 (Cat. No. 4399).
External Portal InformationChemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of GNF 5 is reviewed on the chemical probes website.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Iacob et al (2011) Allosteric interactions between the myristate- and ATP-site of the Abl kinase. PLoS One 6 e15929. PMID: 21264348.
Deng et al (2010) Expanding the diversity of allosteric Bcr-Abl inhibitors. J.Med.Chem. 53 6934. PMID: 20828158.
Zhang et al (2010) Targeting Bcr-Abl by combining allosteric with ATP-binding-site inhibitors. Nature 463 501. PMID: 20072125.
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Keywords: GNF 5, supplier, GNF5, Bcr-Abl, kinase, allosteric, inhbitors, inhibits, selective, bcrabl, bcr, abl, fusion, philadelphia, chromosome, chronic, myeloid, leukemia, leukaemia, CML, allosteric, Tocris Bioscience, Abl Kinase Inhibitor products
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