Cat. No. 4906
Chemical Name: 4-[(3-Phenoxyphenyl)methyl]-1-piper
Biological ActivityPotent and selective monoacylglycerol lipase (MAGL) inhibitor (IC50 = 3.7 nM). Displays >1000-fold selectivity for MAGL over fatty acid amide hydrolase (IC50 = 20.6 μM). Analog of JZL 195 (Cat. No. 4715).
Licensing InformationSold under license from The Scripps Research Institute
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Chang et al (2012) Highly selective inhibitors of monoacylglycerol lipase bearing a reactive group that is bioisosteric with endocannabinoid substrates. Chem.Biol. 19 579. PMID: 22542104.
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Keywords: JW 642, supplier, JW642, MAGL, monoacylglycerol, potent, selective, inhibitors, inhibits, lipases, esterases, Tocris Bioscience, Monoacylglycerol Lipase Inhibitor products