NU 9056

Cat. No. 4903

NU 9056 C6H4N2S4 [1450644-28-6]

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Chemical Name: 5-(1,2-Thiazol-5-yldisulfanyl)-1,2-thiazole

Biological Activity

Selective KAT5 (Tip60) histone acetyltransferase inhibitor (IC50 values are < 2, 60, 36, and >100 μM for KAT5, p300, pCAF and GCN5, respectively). Inhibits protein acetylation in prostate cancer cell lines and blocks DNA damage response. Decreases proliferation of LNCaP cells; induces apoptosis via caspase activation.

Technical Data

Soluble in DMSO (supplied pre-dissolved in DMSO, 10mg/ml)
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Coffey et al (2012) Characterisation of a Tip60 specific inhibitor, NU9056, in prostate cancer. PLoS One 7 e45539. PMID: 23056207.

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Keywords: NU 9056, supplier, NU9056, KAT5, Tip60, histone, acetyltransferase, HAT, inhibitors, inhibits, acetylation, dna, damage, proliferation, apoptosis, caspase, Tocris Bioscience, Histone Acetyltransferase Inhibitor products

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