NU 9056

Cat. No. 4903

NU 9056 C6H4N2S4 [1450644-28-6]

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Chemical Name: 5-(1,2-Thiazol-5-yldisulfanyl)-1,2-thiazole

Biological Activity

Selective KAT5 (Tip60) histone acetyltransferase inhibitor (IC50 values are < 2, 60, 36, and >100 μM for KAT5, p300, pCAF and GCN5, respectively). Inhibits protein acetylation in prostate cancer cell lines and blocks DNA damage response. Decreases proliferation of LNCaP cells; induces apoptosis via caspase activation.

Technical Data

M.Wt:
232.37
Formula:
C6H4N2S4
Solubility:
Soluble in DMSO (supplied pre-dissolved in DMSO, 10mg/ml)
Storage:
Store at -20°C
CAS No:
1450644-28-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Coffey et al (2012) Characterisation of a Tip60 specific inhibitor, NU9056, in prostate cancer. PLoS One 7 e45539. PMID: 23056207.

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Citations are publications that use Tocris products.

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Keywords: NU 9056, supplier, NU9056, KAT5, Tip60, histone, acetyltransferase, HAT, inhibitors, inhibits, acetylation, dna, damage, proliferation, apoptosis, caspase, Tocris Bioscience, Histone Acetyltransferase Inhibitor products

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