SNC 162

Cat. No. 1529

SNC 162 C27H37N3O [178803-51-5]

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Chemical Name: 4-[(S)-[(2S,5R)-2,5-Dimethyl-4-(2-propenyl)-1-piperazinyl]phenylmethyl]-N,N-diethylbenzamide

Biological Activity

Potent and selective non-peptide δ-opioid receptor agonist (Ki = 0.63 nM). Displays > 8000-fold selectivity over μ-opioid receptors and is centrally active following systemic administration in vivo.

Technical Data

M.Wt:
419.61
Formula:
C27H37N3O
Solubility:
Soluble to 100 mM in 1eq. HCl
Purity:
>99 %
Storage:
Store at RT
CAS No:
178803-51-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Negus et al (1998) Behavioral effects of the delta-selective opioid agonist SNC80 and related compounds in rhesus monkeys. J.Pharmacol.Exp.Ther. 286 362. PMID: 9655881.

Calderon et al (1997) Probes for narcotic receptor mediated phenomena. 23. Synthesis, opioid receptor binding, and bioassay of the highly selective δ agonist (+)-4-[(αR)-α-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]-N,N-diethylbenzamide (SNC 80) and related novel nonpeptide δ opioid receptor ligands. J.Med.Chem. 40 695. PMID: 9057856.

Knapp et al (1996) Structure-activity relationships for SNC80 and related compounds at cloned human delta and mu opioid receptors. J.Pharmacol.Exp.Ther. 277 1284. PMID: 8667189.

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Citations are publications that use Tocris products. Selected citations for SNC 162 include:

Levoye et al (2015) A Broad G Protein-Coupled Receptor Internalization Assay that Combines SNAP-Tag Labeling, Diffusion-Enhanced Resonance Energy Transfer, and a Highly Emissive Terbium Cryptate. Cell Cycle 6 167. PMID: 26617570.

Parenty et al (2008) CXCR2 chemokine receptor antagonism enhances DOP opioid receptor function via allosteric regulation of the CXCR2-DOP receptor heterodimer. Biochem J 412 245. PMID: 18307412.

Do you know of a great paper that uses SNC 162 from Tocris? If so please let us know.

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Keywords: SNC 162, supplier, Potent, selective, non-peptide, δ-opioid, delta-opioid, agonists, DOP, Receptors, OP1, SNC162, Tocris Bioscience, δ Opioid Receptor Agonist products

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