NSC 405020

Cat. No. 4902

NSC 405020 C12H15Cl2NO [7497-07-6]

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Chemical Name: 3,4-Dichloro-N-(1-methylbutyl)benzamide

Biological Activity

Membrane type-1 matrix metalloproteinase (MT1-MMP) inhibitor (IC50 > 100 μmol/L). Directly interacts with the hemopexin domain (PEX) of MT1-MMP, affecting homodimerization and repressing its pro-tumorigenic activity in vivo. Displays no effect on the catalytic activity of MT1-MMP or MMP-2.

Technical Data

Soluble to 100 mM in DMSO and to 100 mM in ethanol
>99 %
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Remacle et al (2012) Novel MT1-MMP small-molecule inhibitors based on insights into hemopexin domain function in tumor growth. Cancer Res. 72 2339. PMID: 22406620.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for NSC 405020 include:

Clancy et al (2015) Regulated delivery of molecular cargo to invasive tumour-derived microvesicles. Proc Natl Acad Sci U S A 6 6919. PMID: 25897521.

Do you know of a great paper that uses NSC 405020 from Tocris? If so please let us know.

View Related Products by Product Action

Keywords: NSC 405020, supplier, NSC405020, Membrane, type-1, matrix, metalloproteinase, MT1-MMP, inhibitors, inhibits, hemopexin, domains, PEX, pro-tumorigenic, antitumor, MMP2, MMP-2, MMP, Tocris Bioscience, Matrix Metalloprotease Inhibitor products

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