Cat. No. 4902
Chemical Name: 3,4-Dichloro-N-(1-methylbutyl)benza
Biological ActivityMembrane type-1 matrix metalloproteinase (MT1-MMP) inhibitor (IC50 > 100 μmol/L). Directly interacts with the hemopexin domain (PEX) of MT1-MMP, affecting homodimerization and repressing its pro-tumorigenic activity in vivo. Displays no effect on the catalytic activity of MT1-MMP or MMP-2.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Remacle et al (2012) Novel MT1-MMP small-molecule inhibitors based on insights into hemopexin domain function in tumor growth. Cancer Res. 72 2339. PMID: 22406620.
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Citations are publications that use Tocris products. Selected citations for NSC 405020 include:
Clancy et al (2015) Regulated delivery of molecular cargo to invasive tumour-derived microvesicles. Proc Natl Acad Sci U S A 6 6919. PMID: 25897521.
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Keywords: NSC 405020, supplier, NSC405020, Membrane, type-1, matrix, metalloproteinase, MT1-MMP, inhibitors, inhibits, hemopexin, domains, PEX, pro-tumorigenic, antitumor, MMP2, MMP-2, MMP, Tocris Bioscience, Matrix Metalloprotease Inhibitor products
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