Cat. No. 4900
Chemical Name: N-[(3R,4S)-3-[4-(5-cyano-2-thienyl)
Biological ActivityPositive allosteric modulator of AMPA receptors (Ki = 85 nM). Prevents ketamine-induced working memory impairments. Brain penetrant.
Licensing InformationSold for research purposes under agreement from Pfizer Inc.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Shaffer et al (2013) Positive allosteric modulation of AMPA receptors from efficacy to toxicity: the interspecies exposure-response continuum of the novel potentiator PF-4778574. J.Pharmacol.Exp.Ther. 347 212. PMID: 23899905.
Doran et al (2012) An evaluation of using rat-derived single-dose neuropharmacokinetic parameters to project accurately large animal unbound brain drug concentrations. Drug Metab.Dispos. 40 2162. PMID: 22899853.
Roberts et al (2010) Prevention of ketamine-induced working memory impairments by AMPA potentiators in a nonhuman primate model of cognitive dysfunction. Behav.Brain Res. 212 41. PMID: 20347881.
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Keywords: PF 4778574, supplier, PF4778574, pam, positive, allosteric, modulators, potentiators, ampa, cognitive, enhancers, enhancement, brain, penetrant, bbb, Tocris Bioscience, AMPA Receptor Modulator products
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