Cat. No. 4898
Chemical Name: 6-[(4-Fluorophenyl)(4-methyl-1-pipe
Biological Activityγ-secretase modulator. Reduces Aβ42 levels in vitro (EC50 = 390 nM) and in vivo. Orally bioavailable.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Peng et al (2011) Discovery of BIIB042, a potent, selective, and orally bioavailable γ-secretase modulator. ACS Med.Chem.Lett. 2 786. PMID: 24900267.
If you know of a relevant reference for TC-E 5006 please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses TC-E 5006 from Tocris? If so please let us know.
View Related Products by Product Action
Keywords: TC-E 5006, supplier, TC-E5006, biib042, γ-secretase, g-secretase, gamma-secretase, modulators, Aβ42, AB42, Abeta42, amyloid, Tocris Bioscience, γ-Secretase Modulator products
Find multiple products by catalog number
New Products in this Area
Plasminogen activator inhibitor-1 (PAI-1) inhibitorSB 3CT
Selective high affinity MMP2 inhibitor
Follow @Tocris on Twitter
Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.