TC-E 5006

Cat. No. 4898

TC-E 5006 C29H29F4NO2 [1257395-14-4]

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Chemical Name: 6-[(4-Fluorophenyl)(4-methyl-1-piperidinyl)methyl]-a-methyl-4'-(trifluoromethyl)-[1,1'-biphenyl]-3-acetic acid

Biological Activity

γ-secretase modulator. Reduces Aβ42 levels in vitro (EC50 = 390 nM) and in vivo. Orally bioavailable.

Technical Data

M.Wt:
499.54
Formula:
C29H29F4NO2
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
1257395-14-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Peng et al (2011) Discovery of BIIB042, a potent, selective, and orally bioavailable γ-secretase modulator. ACS Med.Chem.Lett. 2 786. PMID: 24900267.

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Citations are publications that use Tocris products.

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Keywords: TC-E 5006, supplier, TC-E5006, biib042, γ-secretase, g-secretase, gamma-secretase, modulators, Aβ42, AB42, Abeta42, amyloid, Tocris Bioscience, γ-Secretase Modulator products

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