CYM 5541

Cat. No. 4897

CYM 5541 C19H28N2O2 [945128-26-7]

Price and Availability

For CYM 5541 pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: N,N-Dicyclohexyl-5-cyclopropyl-3-isoxazolecarboxamide

Biological Activity

Selective sphingosine-1-phosphate receptor 3 (S1P3) allosteric agonist (EC50 = 72-132 nM). Occupies a different space within the ligand binding pocket of S1P3 than S1P. Displays no activity at S1P1, S1P2, S1P4 and S1P5 receptors at concentrations up to 10 μM. Shows no significant activities in a profiling panel of 55 GPCRs, ion channels and transporters.

Technical Data

M.Wt:
316.44
Formula:
C19H28N2O2
Solubility:
Soluble to 100 mM in DMSO and to 50 mM in ethanol
Purity:
>97 %
Storage:
Store at +4°C
CAS No:
945128-26-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

Jo et al (2012) Novel selective allosteric and bitopic ligands for the S1P3 receptor. ACS Chem.Biol. 7 1975. PMID: 22971058.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for CYM 5541 include:

O'Sullivan et al (2016) The dual S1PR1/S1PR5 drug BAF312 (Siponimod) attenuates demyelination in organotypic slice cultures. Nat Commun 13 31. PMID: 26856814.

Hoffmann et al (2015) Fingolimod induces neuroprotective factors in human astrocytes. J Neuroinflammation 12 184. PMID: 26419927.

Do you know of a great paper that uses CYM 5541 from Tocris? If so please let us know.

View Related Products by Target

View Related Products by Product Action

Keywords: CYM 5541, supplier, CYM5541, Selective, S1P3, receptors, allosteric, agonists, SIP, Sphingosine-1-phosphate, Sphingosine, Tocris Bioscience, Sphingosine-1-Phosphate Receptor Agonist products

Quick Order

Find multiple products by catalog number

divider line

Cardiovascular Research Product Guide

Cardiovascular Research Product Guide

Our Cardiovascular Guide highlights over 250 products for cardiovascular research. Request copy or view PDF today.

divider line

Cancer Research Product Guide

Cancer Research Product Guide

Our Cancer Research Guide highlights over 750 products for cancer research. Request copy or view PDF today.

divider line

GPCR Product Listing

GPCR Product Listing

Highlights over 450 products for GPCRs. Request copy or view PDF today.

divider line

New Products in this Area

AR-C 69931 tetrasodium salt

Highly potent P2Y12 antagonist

FTY 720

Potent S1P receptor agonist; also immunosuppresent

Cinacalcet hydrochloride

Calcium-sensing receptor (CaSR) allosteric agonist; also CYP2D2 inhibitor and Ca2+ channel blocker; orally bioavailable

AMG 837 hemicalcium salt

Potent free fatty acid receptor 1 (FFA1/GPR40) partial agonist

UMB 68

GHB receptor ligand

AZD 1283

High affinity P2Y12 antagonist

Ex 26

Potent and selective S1P1 receptor antagonist

ZQ 16

Selective GPR84 agonist

IHR-Cy3

Potent fluorescent Smo antagonist

Ro 6842262

Potent LPA1 antagonist

AMG 853

Potent dual CRTH2 and prostaglandin D2 (PGD2) receptor antagonist

AM 4668

Potent FFA1 (GPR40) agonist

Sign-up for new product e-alerts
divider line

Twitter Updates

Follow @Tocris on Twitter

Follow us on Twitter!

Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.