CYM 5541

Cat. No. 4897

CYM 5541 C19H28N2O2 [945128-26-7]

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Chemical Name: N,N-Dicyclohexyl-5-cyclopropyl-3-isoxazolecarboxamide

Biological Activity

Selective sphingosine-1-phosphate receptor 3 (S1P3) allosteric agonist (EC50 = 72-132 nM). Occupies a different space within the ligand binding pocket of S1P3 than S1P. Displays no activity at S1P1, S1P2, S1P4 and S1P5 receptors at concentrations up to 10 μM. Shows no significant activities in a profiling panel of 55 GPCRs, ion channels and transporters.

Technical Data

M.Wt:
316.44
Formula:
C19H28N2O2
Solubility:
Soluble to 100 mM in DMSO and to 50 mM in ethanol
Purity:
>97 %
Storage:
Store at +4°C
CAS No:
945128-26-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Jo et al (2012) Novel selective allosteric and bitopic ligands for the S1P3 receptor. ACS Chem.Biol. 7 1975. PMID: 22971058.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for CYM 5541 include:

O'Sullivan et al (2016) The dual S1PR1/S1PR5 drug BAF312 (Siponimod) attenuates demyelination in organotypic slice cultures. Nat Commun 13 31. PMID: 26856814.

Hoffmann et al (2015) Fingolimod induces neuroprotective factors in human astrocytes. J Neuroinflammation 12 184. PMID: 26419927.

Do you know of a great paper that uses CYM 5541 from Tocris? If so please let us know.

View Related Products by Product Action

Keywords: CYM 5541, supplier, CYM5541, Selective, S1P3, receptors, allosteric, agonists, SIP, Sphingosine-1-phosphate, Sphingosine, Tocris Bioscience, Sphingosine-1-Phosphate Receptor Agonist products

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