Cat. No. 4897
Chemical Name: N,N-Dicyclohexyl-5-cyclopropyl-3-is
Biological ActivitySelective sphingosine-1-phosphate receptor 3 (S1P3) allosteric agonist (EC50 = 72-132 nM). Occupies a different space within the ligand binding pocket of S1P3 than S1P. Displays no activity at S1P1, S1P2, S1P4 and S1P5 receptors at concentrations up to 10 μM. Shows no significant activities in a profiling panel of 55 GPCRs, ion channels and transporters.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Jo et al (2012) Novel selective allosteric and bitopic ligands for the S1P3 receptor. ACS Chem.Biol. 7 1975. PMID: 22971058.
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Citations are publications that use Tocris products. Selected citations for CYM 5541 include:
O'Sullivan et al (2016) The dual S1PR1/S1PR5 drug BAF312 (Siponimod) attenuates demyelination in organotypic slice cultures. Nat Commun 13 31. PMID: 26856814.
Hoffmann et al (2015) Fingolimod induces neuroprotective factors in human astrocytes. J Neuroinflammation 12 184. PMID: 26419927.
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Keywords: CYM 5541, supplier, CYM5541, Selective, S1P3, receptors, allosteric, agonists, SIP, Sphingosine-1-phosphate, Sphingosine, Tocris Bioscience, Sphingosine-1-Phosphate Receptor Agonist products
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