Cat. No. 4896
Chemical Name: N-(5-Chloro-6-methyl-2-benzothiazol
Biological ActivitySelective inhibitor of casein kinase (CK) 1δ (IC50 values are 290 nM, 1.3 μM and 2.5 μM for CK1δ, ε and α); displays no inhibitory activity at CK2. Inhibits CK1δ-dependent phosphorylation and degradation of PER1 protein. Shown to lengthen the circadian period in U2OS cells, with minimal effect on amplitude.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Lee et al (2011) A small molecule modulates circadian rhythms through phosphorylation of the period protein. Agnew Chem.Int.Ed.Engl. 50 10608. PMID: 21954091.
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Citations are publications that use Tocris products. Selected citations for LH 846 include:
Causton et al (2015) Metabolic cycles in yeast share features conserved among circadian rhythms. Curr.Biol. 25 1056. PMID: 25866393.
Zemp et al (2014) CK1δ and CK1ε are components of human 40S subunit precursors required for cytoplasmic 40S maturation. J Cell Sci 127 1242. PMID: 24424021.
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Keywords: LH 846, supplier, LH846, casein, kinase, I, CK1, CK1d, CK1delta, CK1δ, selective, inhibitors, inhibits, circadian, rhythm, clock, Tocris Bioscience, Casein Kinase 1 Inhibitor products
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