ML 298 hydrochloride

Cat. No. 4895

ML 298 hydrochloride C22H23F3N4O2.HCl

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Chemical Name: 3,4-Difluoro-N-[2-[1-(3-fluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]dec-8-yl]ethyl]benzamide hydrochloride

Biological Activity

Selective inhibitor of phospholipase D2 (PLD2) (IC50 values are 355 and >20,000 nM for PLD2 and PLD1, respectively). Decreases invasive migration in U87-MG glioblastoma cells, without affecting cell viability.

Technical Data

M.Wt:
468.9
Formula:
C22H23F3N4O2.HCl
Solubility:
Soluble to 25 mM in DMSO
Storage:
Desiccate at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

O'Reilly et al (2013) Development of dual PLD1/2 adn PLD2 selective inhibitors from a common 1,3,8-triazaspiro[4.5]decane core: discovery of ML298 and ML299 that decrease invasive migration in U87-MG glioblastoma cells. J.Med.Chem. 56 2695. PMID: 23445448.

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Keywords: ML 298 hydrochloride, supplier, ML298, hydrochloride, PLD2, phospholipase, 2, inhibitors, inhibits, selective, Tocris Bioscience, Phospholipase Inhibitor products

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