Cat. No. 4893
Chemical Name: [7-(6-Amino-3-pyridinyl)-2,3-dihydr
Biological ActivityPotent and selective mTOR inhibitor (IC50 = 9.9 nM). Inhibits mTOR activity in an ATP-competitive manner. Exhibits >300-fold selectivity for mTOR over PI 3-K and a range of other kinases. Displays antitumor activity in athymic nude mice implanted with tumor xenografts.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Takeuchi et al (2013) Discovery of a novel class of highly potent, selective, ATP-competitive, and orally bioavailable inhibitors of the mammalian target of rapamycin (mTOR). J.Med.Chem. 56 2218. PMID: 23394126.
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Keywords: XL 388, supplier, XL388, potent, selective, mtor, inhibitors, inhibits, kinases, antitumor, ATP-competetive, Tocris Bioscience, mTOR Inhibitor products
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