Cat. No. 4890
Chemical Name: 5-[[5-(2,8-Dimethyl-5H-dibenzo[a,d]
Biological ActivitySelective, competitive P2Y2 receptor antagonist. Inactive against a panel of 37 other receptors at a concentration of 10 μM. Inhibits ATP-γS-induced mucin secretion in bronchial epithelial cells (IC50 = 1 μM). Inhibits P2Y2 receptor-induced β-arrestin translocation in vitro (pA2 = 37.2-51.3 nM).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Rafehi et al (2017) Synthesis, characterization, and in vitro evaluation of the selective P2Y2 receptor antagonist AR-C118925. Purinergic.Signal. 13 89. PMID: 27766552.
Kemp et al (2004) Nucleotide-mediated mucin secretion from differentiated human bronchial epithelial cells. Am.J.Respir.Cell Mol.Biol. 31 446. PMID: 15231488.
Meghani (2002) The design of P2Y2 antagonists for the treatment of inflammatory diseases. Abstract of papers, 224th ACS National Meeting, Boston, MA.
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Keywords: AR-C 118925XX, supplier, AR-C118925XX, selective, competitive, purinergics, p2y2, antagonists, Tocris Bioscience, Purinergic (P2Y) Receptor Antagonist products
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