KHS 101 hydrochloride

Cat. No. 4888

KHS 101 hydrochloride C18H21N5S.HCl

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Chemical Name: N4-(2-Methylpropyl)-N2-[(2-phenyl-4-thiazolyl)methyl]-2,4-pyrimidinediamine hydrochloride

Biological Activity

Selective inducer of neuronal differentiation; induces neuronal differentiation in cultured hippocampal neural progenitor cells (NPCs) by interacting with TACC3 (EC50 ~1 μM). Suppresses astrocyte formation. Also induces acceleration of neuronal differentiation in the hippocampal dentate gyrus in vivo.

Technical Data

M.Wt:
375.92
Formula:
C18H21N5S.HCl
Solubility:
Soluble to 50 mM in DMSO and to 50 mM in ethanol
Purity:
>98 %
Storage:
Desiccate at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Wurdak et al (2010) A small molecule accelerates neuronal differentiation in the adult rat. Proc.Natl.Acad.Sci.USA. 107 16542. PMID: 20823227.

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Keywords: KHS 101 hydrochloride, supplier, KHS101, hydrochloride, transforming, acidic, coiled-coil-containing, protein, 3, TACC3, NPC, hippocampal, neural, progenitors, cells, neuronal, differentiation, maturing, neurons, differentiated, selective, activators, [1262770-73-9], Tocris Bioscience, Neural Stem Cells products

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