OAC-1

Cat. No. 4887

OAC-1 C14H11N3O [300586-90-7]

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Chemical Name: N-1H-Pyrrolo[2,3-c]pyridin-5-ylbenzamide

Biological Activity

Oct4 activator. Enhances and accelerates iPSC reprogramming in the presence of 4F (Oct4, Sox2, c-Myc and Klf4) by ~20-fold compared to 4F alone. Induces mRNA expression of Oct4, Sox2 and Nanog and also Tet1. Displays no effects on p53-p21 pathway or Wnt-β-catenin signaling.

Technical Data

M.Wt:
237.26
Formula:
C14H11N3O
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
300586-90-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Li et al (2012) Identification of Oct4-activating compounds that enhance reprogramming efficiency. Proc.Natl.Acad.Sci.U S A 109 20853. PMID: 23213213.

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Keywords: OAC-1, supplier, OAC1, iPSCs, reprogramming, factors, Oct4, activators, Sox2, Nanog, inducers, enhances, accelerates, Tocris Bioscience, Reprogramming products

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Stem Cells Review

Written by K. Clarke et al

Stem Cells Scientific Review

Our Stem Cells review gives an overview of the use of small molecules in the control of stem cell growth & differentiation and somatic cell reprogramming. Request copy or view PDF today.

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