Cat. No. 4887
Chemical Name: N-1H-Pyrrolo[2,3-c]pyridin-5-ylbenz
Biological ActivityOct4 activator. Enhances and accelerates iPSC reprogramming in the presence of 4F (Oct4, Sox2, c-Myc and Klf4) by ~20-fold compared to 4F alone. Induces mRNA expression of Oct4, Sox2 and Nanog and also Tet1. Displays no effects on p53-p21 pathway or Wnt-β-catenin signaling.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Li et al (2012) Identification of Oct4-activating compounds that enhance reprogramming efficiency. Proc.Natl.Acad.Sci.U S A 109 20853. PMID: 23213213.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses OAC-1 from Tocris? If so please let us know.
View Related Products by Product Action
Keywords: OAC-1, supplier, OAC1, iPSCs, reprogramming, factors, Oct4, activators, Sox2, Nanog, inducers, enhances, accelerates, Tocris Bioscience, Reprogramming products
Find multiple products by catalog number
New Products in this Area
Induces reprogramming of fibroblasts into functional cardiomyocytesO4I2
Oct3/4 inducer; induces expression of pluripotent-associated genes
November 12 - 16, 2016
San Diego, CA, USA