RU-SKI 43 hydrochloride
Cat. No. 4886
Chemical Name: 2-((2-Methylbutyl)amino)-1-(4-((3-m
Biological ActivityHedgehog acyltransferase (Hhat) inhibitor (IC50 = 850 nM). Inhibits Sonic Hedgehog N (ShhN) palmitoylation in vitro. Has no effect on porcupine-induced fatty acid acylation of Wnt39a. Attenuates pancreatic cancer cell proliferation. Cell permeable.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Petrova et al (2014) Hedgehog acyltransferase as a target in pancreatic ductal adenocarcinoma. Oncogene 34 263. PMID: 24469057.
Petrova et al (2013) Inhibitors of Hedgehog acyltransferase block Sonic Hedgehog signaling. Nat.Chem.Biol. 9 247. PMID: 23416332.
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Keywords: RU-SKI 43 hydrochloride, supplier, RU-SKI43, Hydrochloride, Hedgehog, acyltransferase, inhibitors, inhibits, Hh, sonic, ShhN, Hhat, palmitoylation, Tocris Bioscience, Hedgehog Signaling Inhibitor products
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