RU-SKI 43 hydrochloride

Cat. No. 4886

RU-SKI 43 hydrochloride C22H30N2O2S.HCl

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Chemical Name: 2-((2-Methylbutyl)amino)-1-(4-((3-methylphenoxy)methyl-6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)ethanone hydrochloride

Biological Activity

Hedgehog acyltransferase (Hhat) inhibitor (IC50 = 850 nM). Inhibits Sonic Hedgehog N (ShhN) palmitoylation in vitro. Has no effect on porcupine-induced fatty acid acylation of Wnt39a. Attenuates pancreatic cancer cell proliferation. Cell permeable.

Technical Data

Soluble to 100 mM in DMSO
>98 %
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Petrova et al (2014) Hedgehog acyltransferase as a target in pancreatic ductal adenocarcinoma. Oncogene 34 263. PMID: 24469057.

Petrova et al (2013) Inhibitors of Hedgehog acyltransferase block Sonic Hedgehog signaling. Nat.Chem.Biol. 9 247. PMID: 23416332.

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Keywords: RU-SKI 43 hydrochloride, supplier, RU-SKI43, Hydrochloride, Hedgehog, acyltransferase, inhibitors, inhibits, Hh, sonic, ShhN, Hhat, palmitoylation, Tocris Bioscience, Hedgehog Signaling Inhibitor products

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