RU-SKI 43 hydrochloride
Cat. No. 4886
Chemical Name: 2-((2-Methylbutyl)amino)-1-(4-((3-m
Biological ActivityHedgehog acyltransferase (Hhat) inhibitor (IC50 = 850 nM). Inhibits Sonic Hedgehog N (ShhN) palmitoylation in vitro. Has no effect on porcupine-induced fatty acid acylation of Wnt39a. Attenuates pancreatic cancer cell proliferation. Cell permeable.
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Petrova et al (2014) Hedgehog acyltransferase as a target in pancreatic ductal adenocarcinoma. Oncogene 34 263. PMID: 24469057.
Petrova et al (2013) Inhibitors of Hedgehog acyltransferase block Sonic Hedgehog signaling. Nat.Chem.Biol. 9 247. PMID: 23416332.
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Keywords: RU-SKI 43 hydrochloride, supplier, RU-SKI43, Hydrochloride, Hedgehog, acyltransferase, inhibitors, inhibits, Hh, sonic, ShhN, Hhat, palmitoylation, Tocris Bioscience, Hedgehog Signaling Inhibitor products
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