CU CPT 22
Cat. No. 4884
Chemical Name: 3,4,6-Trihydroxy-2-methoxy-5-oxo-5H
Biological ActivitySelective toll-like receptor 1/2 (TLR1/2) inhibitor (IC50 = 0.58 μM). Exhibits no activity at TLR2/TLR6, TLR3, TLR4 and TLR7 or a panel of 10 representative kinases. Inhibits the release of proinflammatory cytokines TNF-α and IL-1β.
Licensing InformationSold under license from the University of Colorado
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Cheng et al (2012) Discovery of small-molecule inhibitors of the TLR1/TLR2 complex. Angew Chem.Int.Ed.Engl. 51 12246. PMID: 22969053.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products. Selected citations for CU CPT 22 include:
Ghonime et al (2015) Inflammasome priming is similar for francisella species that differentially induce inflammasome activation. Nucleic Acids Res 10 e0127278. PMID: 25993107.
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Keywords: CU CPT 22, supplier, CUCPT22, toll-like, receptors, inhibitors, inhibits, selective, proinflammatory, cytokines, TLR, TLR1, TLR2, TRL1/TLR2, Tocris Bioscience, Toll-like Receptor Inhibitor products
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