Cat. No. 4884

CU CPT 22 C19H22O7 [1416324-85-0]

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Chemical Name: 3,4,6-Trihydroxy-2-methoxy-5-oxo-5H-benzocycloheptene-8-carboxylic acid hexyl ester

Biological Activity

Selective toll-like receptor 1/2 (TLR1/2) inhibitor (IC50 = 0.58 μM). Exhibits no activity at TLR2/TLR6, TLR3, TLR4 and TLR7 or a panel of 10 representative kinases. Inhibits the release of proinflammatory cytokines TNF-α and IL-1β.

Licensing Information

Sold under license from the University of Colorado

Technical Data

Soluble to 100 mM in DMSO and to 50 mM in ethanol
>98 %
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Cheng et al (2012) Discovery of small-molecule inhibitors of the TLR1/TLR2 complex. Angew Chem.Int.Ed.Engl. 51 12246. PMID: 22969053.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for CU CPT 22 include:

Ghonime et al (2015) Inflammasome priming is similar for francisella species that differentially induce inflammasome activation. Nucleic Acids Res 10 e0127278. PMID: 25993107.

Do you know of a great paper that uses CU CPT 22 from Tocris? If so please let us know.

View Related Products by Product Action

Keywords: CU CPT 22, supplier, CUCPT22, toll-like, receptors, inhibitors, inhibits, selective, proinflammatory, cytokines, TLR, TLR1, TLR2, TRL1/TLR2, Tocris Bioscience, Toll-like Receptor Inhibitor products

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