Cat. No. 4883

CU CPT 4a C18H13ClFNO3S [1279713-77-7]

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Chemical Name: N-[(3-Chloro-6-fluorobenzo[b]thien-2-yl)carbonyl]-D-phenylalanine

Biological Activity

Selective TLR3 inhibitor (IC50 = 3.44 μM in RAW 264.7 cells); suppresses downstream signaling pathways mediated by the TLR3/dsRNA complex, inhibiting TNF-α and IL-1β production in whole cells. Reduces death of crypt cells and improves gastrointestinal syndrome in mice.

Licensing Information

Sold under license from the University of Colorado

Technical Data

Soluble to 100 mM in DMSO and to 50 mM in 1eq. NaOH
>98 %
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Takemura et al (2014) Blockade of TLR3 protects mice from lethal radiation-induced gastrointestinal syndrome. Nat.Commun. 18. PMID: 24637670 .

Cheng et al (2011) Small-molecule inhibitors of the TLR3/dsRNA complex. J.Am.Chem.Soc. 133 3764. PMID: 21355588.

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Citations are publications that use Tocris products.

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Keywords: CU CPT 4a, supplier, CUCPT4a, toll, like, receptors, ligands, antagonists, TLR3, inflammation, TNF-, #945, TNF-1, TNF-alpha, IL-#946, IL-b, IL-beta, Tocris Bioscience, Toll-like Receptor Inhibitor products

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