CU CPT 4a

Cat. No. 4883

CU CPT 4a C18H13ClFNO3S [1279713-77-7]

Price and Availability

For CU CPT 4a pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: N-[(3-Chloro-6-fluorobenzo[b]thien-2-yl)carbonyl]-D-phenylalanine

Biological Activity

Selective TLR3 inhibitor (IC50 = 3.44 μM in RAW 264.7 cells); suppresses downstream signaling pathways mediated by the TLR3/dsRNA complex, inhibiting TNF-α and IL-1β production in whole cells.

Licensing Information

Sold under license from the University of Colorado

Technical Data

M.Wt:
377.82
Formula:
C18H13ClFNO3S
Solubility:
Soluble to 100 mM in DMSO and to 50 mM in 1eq. NaOH
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
1279713-77-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Cheng et al (2011) Small-molecule inhibitors of the TLR3/dsRNA complex. J.Am.Chem.Soc. 133 3764. PMID: 21355588.

If you know of a relevant reference for CU CPT 4a please let us know.

Citations are publications that use Tocris products.

Do you know of a great paper that uses CU CPT 4a from Tocris? If so please let us know.

View Related Products by Target

View Related Products by Product Action

Keywords: CU CPT 4a, supplier, CUCPT4a, toll, like, receptors, ligands, antagonists, TLR3, inflammation, TNF-, #945, TNF-1, TNF-alpha, IL-#946, IL-b, IL-beta, Tocris Bioscience, Toll-like Receptor Inhibitor products

Quick Order

Find multiple products by catalog number

divider line

Cancer Research Product Guide

Cancer Research Product Guide

Our Cancer Research Guide highlights over 750 products for cancer research. Request copy or view PDF today.

divider line

Immunology Guide

Immunology Product Listing

Our Immunology listing highlights over 190 products for immunology research. Request copy or view PDF today.

divider line

Toll-like Receptor Pathway

Toll-like Receptor Signaling Pathway

Toll-like receptors are important in the inflammatory and adaptive and innate immune responses against threatening microbes. View pathway or download PDF today.

divider line

New Products in this Area

BOP

Dual α9β/1α4β1 integrin inhibitor; preferentially mobilizes HSCs

ATN 161

α5β1 integrin receptor antagonist

FSL 1

TLR2/6 agonist (also a putative TLR10 ligand)

Sign-up for new product e-alerts
divider line

LinkedIn Updates

Follow Tocris on LinkedIn

Follow us on LinkedIn!

Visit our LinkedIn page for the latest Tocris news, events and updates.