CU CPT 4a

Cat. No. 4883

CU CPT 4a C18H13ClFNO3S [1279713-77-7]

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Chemical Name: N-[(3-Chloro-6-fluorobenzo[b]thien-2-yl)carbonyl]-D-phenylalanine

Biological Activity

Selective TLR3 inhibitor (IC50 = 3.44 μM in RAW 264.7 cells); suppresses downstream signaling pathways mediated by the TLR3/dsRNA complex, inhibiting TNF-α and IL-1β production in whole cells.

Licensing Information

Sold under license from the University of Colorado

Technical Data

M.Wt:
377.82
Formula:
C18H13ClFNO3S
Solubility:
Soluble to 100 mM in DMSO and to 50 mM in 1eq. NaOH
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
1279713-77-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Cheng et al (2011) Small-molecule inhibitors of the TLR3/dsRNA complex. J.Am.Chem.Soc. 133 3764. PMID: 21355588.

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Keywords: CU CPT 4a, supplier, CUCPT4a, toll, like, receptors, ligands, antagonists, TLR3, inflammation, TNF-, #945, TNF-1, TNF-alpha, IL-#946, IL-b, IL-beta, Tocris Bioscience, Toll-like Receptor Inhibitor products

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