LUF 6283

Cat. No. 4881

LUF 6283 C8H12N2O2 [92933-48-7]

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Chemical Name: 5-Butyl-1H-pyrazole-3-carboxylic acid

Biological Activity

Partial agonist of hydroxycarboxylic acid receptor 2 (HCA2) (Ki = 0.55 μM). Thought to lower plasma very-low-density lipoprotein (VLDL)-triglyceride levels by affecting hepatic VLDL production in normolipidemic C57BL/6 mice.

Technical Data

M.Wt:
168.19
Formula:
C8H12N2O2
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
92933-48-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

Li et al (2012) Effects of pyrazole partial agonists on HCA2-mediated flushing and VLDL-triglyceride levels in mice. Br.J.Pharmacol. 167 818. PMID: 22616721.

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Keywords: LUF 6283, supplier, LUF6283, HCA2, hydroxycarboxylic, acid, receptors, GPR109A, HM74A, partial, agonists, Tocris Bioscience, Hydroxycarboxylic Acid Receptor Agonist products

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