Cat. No. 4878
Chemical Name: (Z,Z)-4,4'-[1,3-Phenylenebis(oxy-4,1
Biological ActivityPotent and selective lysophosphatidic acid 2 (LPA2) receptor antagonist (IC50 values are 8.9, 1230 and 27354 nM for LPA2, LPA3 and LPA1 receptors respectively, in a LPA-elicited calcium mobilization assay).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Fells et al (2009) Structure-based drug design identifies novel LPA3 antagonists. Bioorg.Med.Chem. 17 7457. PMID: 19800804.
Fells et al (2008) Identification of non-lipid LPA3 antagonists by virtual screening. Bioorg.Med.Chem. 16 6207. PMID: 18467108.
If you know of a relevant reference for H2L5186303 please let us know.
Citations are publications that use Tocris products. Selected citations for H2L5186303 include:
Wu et al (2015) Mechanosensitive PPAP2B Regulates Endothelial Responses to Atherorelevant Hemodynamic Forces. PLoS One 117 e41. PMID: 26034042.
Do you know of a great paper that uses H2L5186303 from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: H2L5186303, supplier, lysophosphatidic, acid, 2, receptors, LPA2, antagonists, Tocris Bioscience, Lysophosphatidic Acid Receptor Antagonist products
Find multiple products by catalog number
New Products in this Area
Irreversible P2Y12 antagonist; antiplatelet and orally activeBigLEN (rat)
Potent GPR171 agonistBigLEN (mouse)
P2Y1 allosteric antagonistAC 265347
CaSR biased allosteric modulator7α,25-Dihydroxycholesterol
Highly potent GPR183 (EBI2) agonistAR-C 69931 tetrasodium salt
Highly potent P2Y12 antagonistFTY 720
Potent S1P receptor agonist; also immunosuppressantCinacalcet hydrochloride
Calcium-sensing receptor (CaSR) allosteric agonist; also CYP2D2 inhibitor and Ca2+ channel blocker; orally bioavailableAMG 837 hemicalcium salt
Potent free fatty acid receptor 1 (FFA1/GPR40) partial agonistUMB 68
GHB receptor ligand
Follow @Tocris on Twitter
Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.