H2L5186303

Cat. No. 4878

H2L5186303 C26H20N2O8 [139262-76-3]

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Chemical Name: (Z,Z)-4,4'-[1,3-Phenylenebis(oxy-4,1-phenyleneimino)]bis[4-oxo-2-butenoic acid

Biological Activity

Potent and selective lysophosphatidic acid 2 (LPA2) receptor antagonist (IC50 values are 8.9, 1230 and 27354 nM for LPA2, LPA3 and LPA1 receptors respectively, in a LPA-elicited calcium mobilization assay).

Technical Data

M.Wt:
488.45
Formula:
C26H20N2O8
Solubility:
Soluble to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
139262-76-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Fells et al (2009) Structure-based drug design identifies novel LPA3 antagonists. Bioorg.Med.Chem. 17 7457. PMID: 19800804.

Fells et al (2008) Identification of non-lipid LPA3 antagonists by virtual screening. Bioorg.Med.Chem. 16 6207. PMID: 18467108.

If you know of a relevant reference for H2L5186303 please let us know.

Citations are publications that use Tocris products. Selected citations for H2L5186303 include:

Wu et al (2015) Mechanosensitive PPAP2B Regulates Endothelial Responses to Atherorelevant Hemodynamic Forces. PLoS One 117 e41. PMID: 26034042.

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Keywords: H2L5186303, supplier, lysophosphatidic, acid, 2, receptors, LPA2, antagonists, Tocris Bioscience, Lysophosphatidic Acid Receptor Antagonist products

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