CaCCinh-A01

Cat. No. 4877

CaCCinh-A01 C18H21NO4S [407587-33-1]

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Chemical Name: 6-(1,1-Dimethylethyl)-2-[(2-furanylcarbonyl)amino]-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid

Biological Activity

Calcium-activated chloride channel (CaCC) inhibitor (IC50 ~ 10 μM). Inhibits CaCC currents in human bronchial and intestinal cells. Also inhibits TMEM16A channels (IC50 = 2.1 μM, in TMEM16A-expressing FRT cells).

Technical Data

M.Wt:
347.43
Formula:
C18H21NO4S
Solubility:
Soluble to 100 mM in DMSO and to 10 mM in ethanol with gentle warming
Purity:
>99 %
Storage:
Store at -20°C
CAS No:
407587-33-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Namkung et al (2011) TMEM16A inhibitors reveal TMEM16A as a minor component of calcium-activated chloride channel conductance in airway and intestinal epithelial cells. J.Biol.Chem. 286 2365. PMID: 21084298.

De La Fuente et al (2008) Small-molecule screen identifies inhibitors of a human intestinal calcium-activated chloride channel. Mol.Pharmacol. 73 758. PMID: 18083779.

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Keywords: CaCCinh-A01, supplier, calcium-activated, chloride, channels, CaCC, inhibitors, inhibits, TMEM16A, Tocris Bioscience, Calcium-activated Chloride Channel Blocker products

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