Cat. No. 4876
Chemical Name: 3,4,5-Trimethoxy-N-(2-methoxyethyl)
Biological ActivityTMEM16A (ANO1) calcium-activated chloride channel (CaCC) activator (EC50 = 3 μM). Ca2+-independent. Displays no effect on CFTR Cl- or ENaC Na+ conductance. Stimulates submucosal gland secretion in human bronchi.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Namkung et al (2011) Small-molecule activators of TMEM16A, a calcium-activated chloride channel, stimulate epithelial chloride secretion and intestinal contraction. FASEB J. 25 4048. PMID: 21836025.
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Keywords: Eact, supplier, TMEM16A, ANO1, calcium-activated, chloride, channels, CaCC, activators, activates, anoctamin-1, submucosal, secretion, Tocris Bioscience, Chloride Channel Activator products
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