Cat. No. 4876
Chemical Name: 3,4,5-Trimethoxy-N-(2-methoxyethyl)
Biological ActivityTMEM16A (ANO1) calcium-activated chloride channel (CaCC) activator (EC50 = 3 μM). Also transient receptor potential vanilloid 1 (TRPV1) channel activator (EC50 = 11.6 μM). Ca2+-independent. Displays no effect on CFTR Cl- or ENaC Na+ conductance. Stimulates submucosal gland secretion in human bronchi.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Liu et al (2016) Eact, a small molecule activator of TMEM16A, activates TRPV1 and elicits pain- and itch-related behaviours. Br.J.Pharmacol. 173 1208. PMID: 26756551.
Namkung et al (2011) Small-molecule activators of TMEM16A, a calcium-activated chloride channel, stimulate epithelial chloride secretion and intestinal contraction. FASEB J. 25 4048. PMID: 21836025.
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Citations are publications that use Tocris products.
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Keywords: Eact, supplier, TMEM16A, ANO1, calcium-activated, chloride, channels, CaCC, activators, activates, anoctamin-1, submucosal, secretion, Tocris Bioscience, Calcium-activated Chloride Channel Activator products