Cat. No. 4874
Chemical Name: N-[4-[2,2,2-Trifluoro-1-hydroxy-1-(
Biological ActivityAgonist of retinoic acid receptor-related orphan receptors (ROR) RORα/γ. Increases transcription of RORα target genes; thought to increase p53 stability.
Licensing InformationSold under license from The Scripps Research Institute.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Wang et al (2012) Regulation of p53 stability and apoptosis by a ROR agonist. PLoS One 7 e34921. PMID: 22509368.
Wang et al (2010) Identification of a synthetic agonist for the orphan nuclear receptors RORα and RORγ, SR1078. ACS Chem.Biol. 5 1029. PMID: 20735016.
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Keywords: SR 1078, supplier, SR1078, retinoic, acid, receptor-related, orphan, receptor, RORα, RORalpha, RORa, RORgamma, RORγ, RORg, agonists, Tocris Bioscience, Retinoic Acid-related Orphan Receptor Agonist products