SR 1078

Cat. No. 4874

SR 1078 C17H10F9NO2 [1246525-60-9]

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Chemical Name: N-[4-[2,2,2-Trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-4-(trifluoromethyl)benzamide

Biological Activity

Agonist of retinoic acid receptor-related orphan receptors (ROR) RORα/γ. Increases transcription of RORα target genes; thought to increase p53 stability.

Licensing Information

Sold under license from The Scripps Research Institute.

Technical Data

M.Wt:
431.25
Formula:
C17H10F9NO2
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
1246525-60-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

Wang et al (2012) Regulation of p53 stability and apoptosis by a ROR agonist. PLoS One 7 e34921. PMID: 22509368.

Wang et al (2010) Identification of a synthetic agonist for the orphan nuclear receptors RORα and RORγ, SR1078. ACS Chem.Biol. 5 1029. PMID: 20735016.

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Keywords: SR 1078, supplier, SR1078, retinoic, acid, receptor-related, orphan, receptor, RORα, RORalpha, RORa, RORgamma, RORγ, RORg, agonists, Tocris Bioscience, Retinoic Acid-related Orphan Receptor Agonist products

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