KML 29

Cat. No. 4872

KML 29 C24H21F6NO7 [1380424-42-9]

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Chemical Name: 4-[Bis(1,3-benzodioxol-5-yl)hydroxymethyl]-1-piperidinecarboxylic acid 2,2,2-trifluoro-1-(trifluoromethyl)ethyl ester

Biological Activity

Highly selective and potent monoacylglycerol lipase (MAGL) inhibitor. Exhibits potent inhibition of human, mouse and rat MAGL (IC50 values are 5.9, 15 and 43 nM, respectively). Exhibits no detectable inhibition of FAAH (IC50 > 50000 nM). Potently and selectively blocks hydrolysis of 2-arachidonoylglycerol (2-AG) in mice (IC50 = 2.5 nM and >50 μM for 2-AG and AEA respectively).

Licensing Information

Sold under license from The Scripps Research Institute

Technical Data

M.Wt:
549.42
Formula:
C24H21F6NO7
Solubility:
Soluble to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
1380424-42-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Chang et al (2012) Highly selective inhibitors of monoacylglycerol lipase bearing a reactive group that is bioisosteric with endocannabinoid substrates. Chem.Biol. 19 579. PMID: 22542104.

Ueda et al (2012) Discrimination between two endocannabinoids. Chem.Biol. 19 545. PMID: 22633404.

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Citations are publications that use Tocris products. Selected citations for KML 29 include:

Morena et al (2016) Emotional arousal state influences the ability of amygdalar endocannabinoid signaling to modulate anxiety. Neuropharmacology 111 59. PMID: 27553121.

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Keywords: KML 29, supplier, KML29, MAGL, inhibitor, MAG, lipase, monoacylglycerol, lipase, inhibitors, MGL, endocannabinoids, 2, AG, arachidonoylethanolamide, anandamide, inhibits, Tocris Bioscience, Monoacylglycerol Lipase Inhibitor products

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