H2L 5765834

Cat. No. 4870

H2L 5765834 C21H12N2O7 [420841-84-5]

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Chemical Name: 2,3-Dihydro-2-[3-(4-nitrophenoxy)phenyl]-1,3-dioxo-1H-isoindole-5-carboxylic acid

Biological Activity

Antagonist of the lysophosphatidic acid receptors LPA1, LPA5 and LPA3 (IC50 values are 94, 463 and 752 nM respectively). Exhibits no effect at LPA2 or LPA4 receptors.

Technical Data

M.Wt:
404.33
Formula:
C21H12N2O7
Solubility:
Soluble to 100 mM in DMSO
Purity:
>99 %
Storage:
Store at +4°C
CAS No:
420841-84-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Fells et al (2010) 2D binary QSAR modeling of LPA3 receptor antagonism. J.Mol.Graph Model. 28 828. PMID: 20356772.

Tigyi (2010) Aiming drug discovery at lysophosphatidic acid targets. Br.J.Pharmacol. 161 241. PMID: 20735414.

Williams et al (2009) Unique ligand selectivity of the GPR92/LPA5 lysophosphatidate receptor indicates role in human platelet activation. J.Biol.Chem. 284 17304. PMID: 19366702.

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Citations are publications that use Tocris products.

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Keywords: H2L 5765834, supplier, H2L5765834, lysophosphatidic, acid, receptors, LPA1, LPA3, LPA5, antagonists, Tocris Bioscience, Lysophosphatidic Acid Receptor Antagonist products

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