Cat. No. 4869
Chemical Name: 2-Fluoro-4'-[[4-(4-pyridinylmethyl)-
Biological ActivitySelective inverse agonist of retinoic acid receptor-related orphan receptor γ (RORγ) (Ki = 105 nM; IC50 ~320 nM). Exhibits weak activity at liver X receptor α (LXRα); does not affect the transcriptional activity of farnesoid X receptors (FXR), and has no impact on the transcriptional activity of RORα.
Licensing InformationSold under license from The Scripps Research Institute.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Kumar et al (2012) Identification of SR2211: a potent synthetic RORγ-selective modulator. ACS Chem.Biol. 7 672. PMID: 22292739.
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Citations are publications that use Tocris products.
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Keywords: SR 2211, supplier, SR2211, inverse, agonists, retinoic, acid, receptor-related, orphan, receptor, RORg, RORgamma, RORγ, selective, Tocris Bioscience, Retinoic Acid-related Orphan Receptor Antagonist products
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