SR 2211

Cat. No. 4869

SR 2211 C26H24F7N3O [1359164-11-6]

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Chemical Name: 2-Fluoro-4'-[[4-(4-pyridinylmethyl)-1-piperazinyl]methyl]-a,a-bis(trifluoromethyl)-[1,1'-biphenyl]-4-methanol

Biological Activity

Selective inverse agonist of retinoic acid receptor-related orphan receptor γ (RORγ) (Ki = 105 nM; IC50 ~320 nM). Exhibits weak activity at liver X receptor α (LXRα); does not affect the transcriptional activity of farnesoid X receptors (FXR), and has no impact on the transcriptional activity of RORα.

Licensing Information

Sold under license from The Scripps Research Institute.

Technical Data

Soluble to 100 mM in DMSO and to 50 mM in 1eq. HCl
>98 %
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
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Safety Data Sheet: View Safety Data Sheet

Kumar et al (2012) Identification of SR2211: a potent synthetic RORγ-selective modulator. ACS Chem.Biol. 7 672. PMID: 22292739.

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Keywords: SR 2211, supplier, SR2211, inverse, agonists, retinoic, acid, receptor-related, orphan, receptor, RORg, RORgamma, RORγ, selective, Tocris Bioscience, Retinoic Acid-related Orphan Receptor Antagonist products

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